Air Pollution and the Risk of Parkinson's Disease: A Review.
Air Pollution and the Risk of Parkinson's Disease: A Review.
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DOI：
10.1002/mds.28922
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发表时间：
2022-05
影响因子：
8.6
通讯作者：
Bronstein, Jeff M.
中科院分区：
文献类型：
--
作者：
Murata, Hiromi;Barnhill, Lisa M.;Bronstein, Jeff M.
帕金森病和其他神经退行性疾病的主要特征是蛋白质的病理性积聚、炎症和神经元丢失。虽然有一些已知的遗传风险因素，但大多数病例不能仅用遗传学来解释。因此，必须确定造成风险的环境因素及其作用机制。最近的流行病学研究发现，暴露于空气污染与患帕金森病的风险增加有关，尽管并非所有结果都是一致的。这些研究之间的差异可能是由于测量空气污染的组成部分，用于确定暴露的时间和方法以及对其他变量的校正的差异。有几种潜在的机制可以使空气污染增加患帕金森病的风险，包括直接神经元毒性，诱导全身炎症导致CNS炎症，以及肠道生理学和微生物组的改变。总之，空气污染是帕金森病发展的一个新的危险因素。它促进神经病理学的许多潜在机制已被提及，提供了生物学上的合理性，并且这些机制可能与其他神经退行性疾病（例如阿尔茨海默病）的发展相关。这一领域还处于早期阶段，但更好地了解环境暴露如何影响神经退行性变的发病机制对于降低疾病发病率和寻找疾病改善疗法至关重要。
Parkinson’s disease, and other neurodegenerative disorders, are primarily characterized by pathological accumulation of proteins, inflammation, and neuron loss. Although there are some known genetic risk factors, most cases cannot be explained by genetics alone. Therefore, it is important to determine the environmental factors that confer risk and the mechanisms by which they act. Recent epidemiological studies have found that exposure to air pollution is associated with an increased risk of developing Parkinson’s disease, although not all results are uniform. The variability between these studies is likely due to differences in what components of air pollution are measured, timing and methods used to determine exposures, and correction for other variables. There are several potential mechanisms by which air pollution could act to increase the risk of developing Parkinson’s disease, including direct neuronal toxicity, induction of systemic inflammation leading to CNS inflammation, and alterations in gut physiology and the microbiome. Taken together, air pollution is an emerging risk factor in the development of Parkinson’s disease. A number of potential mechanisms have been implicated by which it promotes neuropathology providing biological plausibility and these mechanisms are likely relevant to the development of other neurodegenerative disorders such as Alzheimer’s disease. This field is in its early stages, but a better understanding of how environmental exposures influence the pathogenesis of neurodegeneration is essential for reducing the incidence of disease and finding disease-modifying therapies.
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α-突触核蛋白与TOM20结合，并抑制在帕金森氏病中进口的线粒体蛋白。
影响因子：
17.1
作者：
Di Maio R;Barrett PJ;Hoffman EK;Barrett CW;Zharikov A;Borah A;Hu X;McCoy J;Chu CT;Burton EA;Hastings TG;Greenamyre JT
通讯作者：
Greenamyre JT
影响因子：
3.8
作者：
Barnhill, Lisa M.;Khuansuwan, Sataree;Bronstein, Jeff M.
通讯作者：
Bronstein, Jeff M.
影响因子：
168.9
作者：
Chartier-Harlin, MC;Kachergus, J;Destée, A
通讯作者：
Destée, A
DOI：
10.1016/0272-0590(86)90199-5
发表时间：
1986-07-01
期刊：
FUNDAMENTAL AND APPLIED TOXICOLOGY
影响因子：
--
作者：
BOND, JA;AYRES, PH;MCCLELLAN, RO
通讯作者：
MCCLELLAN, RO
影响因子：
10.4
作者：
Chen H;Burton EA;Ross GW;Huang X;Savica R;Abbott RD;Ascherio A;Caviness JN;Gao X;Gray KA;Hong JS;Kamel F;Jennings D;Kirshner A;Lawler C;Liu R;Miller GW;Nussbaum R;Peddada SD;Rick AC;Ritz B;Siderowf AD;Tanner CM;Tröster AI;Zhang J
通讯作者：
Zhang J