Research on the premotor symptoms of Parkinson's disease: clinical and etiological implications.
Research on the premotor symptoms of Parkinson's disease: clinical and etiological implications.
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DOI：
10.1289/ehp.1306967
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发表时间：
2013-11
影响因子：
10.4
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Chen H;Burton EA;Ross GW;Huang X;Savica R;Abbott RD;Ascherio A;Caviness JN;Gao X;Gray KA;Hong JS;Kamel F;Jennings D;Kirshner A;Lawler C;Liu R;Miller GW;Nussbaum R;Peddada SD;Rick AC;Ritz B;Siderowf AD;Tanner CM;Tröster AI;Zhang J
背景：帕金森病(PD)的病因和自然病史尚不清楚。一些非运动症状，如营养不良、快速眼动睡眠行为障碍和便秘，可在帕金森病的前驱阶段发展，并早于帕金森病诊断数年。目的：我们研究了帕金森病运动前症状研究的前景和缺陷，并制定了优先顺序和策略，以了解它们的临床和病因学意义。方法：这篇综述基于2012年6月7-8日在北卡罗来纳州研究三角公园的国家环境健康科学研究所举行的研讨会--帕金森氏病先兆症状研讨会。讨论：对帕金森病运动前症状的研究可能为确定高危人群的特征和更好地了解帕金森病的病因提供了一个极好的机会。这样的研究可能导致对新的病因学假说的评估，例如环境毒物或病毒可能在胃肠道或嗅球启动帕金森病的发病机制。目前，我们对帕金森病运动前症状的认识还处于起步阶段，面临着许多障碍。这些症状往往不是帕金森病的特异性症状，对帕金森病早期诊断的阳性预测价值较低。此外，这些运动前症状的病理基础和生物学机制及其与帕金森病发病机制的相关性尚不清楚。结论：这是一个新兴的研究领域，有重要的数据空白需要填补。需要进一步的研究来了解多种运动前症状的患病率及其与帕金森病的病因学相关性。动物实验和机制研究将进一步了解这些运动前症状的生物学原理，并检验新的病因学假说。引文：Chen H，Burton EA，Ross GW，Huang X，Savica R，Abbott Rd，Ascherio A，Cavness JN，Gao X，Gray Ka，Hong JS，Kamel F，Jennings D，Kirshner A，Lawler C，Liu R，Miller GW，Nussbaum R，Peddada SD，Comstock Rick A，Ritz B，Siderowf AD，Tanner CM，Tröster AI，Zhang J.2013。帕金森病运动前症状的研究：临床和病因学意义。环境健康展望121:1245–1252； http://dx.doi.org/10.1289/ehp.1306967
Background: The etiology and natural history of Parkinson’s disease (PD) are not well understood. Some non-motor symptoms such as hyposmia, rapid eye movement sleep behavior disorder, and constipation may develop during the prodromal stage of PD and precede PD diagnosis by years. Objectives: We examined the promise and pitfalls of research on premotor symptoms of PD and developed priorities and strategies to understand their clinical and etiological implications. Methods: This review was based on a workshop, Parkinson’s Disease Premotor Symptom Symposium, held 7–8 June 2012 at the National Institute of Environmental Health Sciences in Research Triangle Park, North Carolina. Discussion: Research on premotor symptoms of PD may offer an excellent opportunity to characterize high-risk populations and to better understand PD etiology. Such research may lead to evaluation of novel etiological hypotheses such as the possibility that environmental toxicants or viruses may initiate PD pathogenesis in the gastrointestinal tract or olfactory bulb. At present, our understanding of premotor symptoms of PD is in its infancy and faces many obstacles. These symptoms are often not specific to PD and have low positive predictive value for early PD diagnosis. Further, the pathological bases and biological mechanisms of these premotor symptoms and their relevance to PD pathogenesis are poorly understood. Conclusion: This is an emerging research area with important data gaps to be filled. Future research is needed to understand the prevalence of multiple premotor symptoms and their etiological relevance to PD. Animal experiments and mechanistic studies will further understanding of the biology of these premotor symptoms and test novel etiological hypothesis. Citation: Chen H, Burton EA, Ross GW, Huang X, Savica R, Abbott RD, Ascherio A, Caviness JN, Gao X, Gray KA, Hong JS, Kamel F, Jennings D, Kirshner A, Lawler C, Liu R, Miller GW, Nussbaum R, Peddada SD, Comstock Rick A, Ritz B, Siderowf AD, Tanner CM, Tröster AI, Zhang J. 2013. Research on the premotor symptoms of Parkinson’s Disease: clinical and etiological implications. Environ Health Perspect 121:1245–1252; http://dx.doi.org/10.1289/ehp.1306967
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影响因子：
4.8
作者：
Boeve, Bradley F.;Molano, Jennifer R.;Ferman, Tanis J.;Smith, Glenn E.;Lin, Siong-Chi;Bieniek, Kevin;Haidar, Wael;Tippmann-Peikert, Maja;Knopman, David S.;Graff-Radford, Neill R.;Lucas, John A.;Petersen, Ronald C.;Silber, Michael H.
通讯作者：
Silber, Michael H.
DOI：
10.1111/j.1460-9568.2008.06346.x
发表时间：
2008-07
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Fleming SM;Tetreault NA;Mulligan CK;Hutson CB;Masliah E;Chesselet MF
通讯作者：
Chesselet MF
影响因子：
9.9
作者：
Abbott, RD;Petrovitch, H;Ross, GW
通讯作者：
Ross, GW
影响因子：
6.1
作者：
Drolet, Robert E.;Cannon, Jason R.;Greenamyre, J. Timothy
通讯作者：
Greenamyre, J. Timothy
影响因子：
5.3
作者：
Fleming, SM;Salcedo, J;Chesselet, MF
通讯作者：
Chesselet, MF