Gene signatures in hepatocellular carcinoma (HCC).
Gene signatures in hepatocellular carcinoma (HCC).
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DOI：
10.1016/j.semcancer.2010.09.002
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发表时间：
2011-02
影响因子：
14.5
通讯作者：
Merle P
中科院分区：
文献类型：
--
作者：
Andrisani OM;Studach L;Merle P
Primary hepatocellular carcinoma (HCC) is a significant human cancer globally, with poor prognosis. New and efficacious therapy strategies are needed as well as new biomarkers for early detection of at-risk patients. In this review, we discuss select microarray studies of human HCCs, and propose a gene signature that has promise for clinical/translational application. This gene signature combines the proliferation cluster of genes and the hepatic cancer initiating/stem cell gene cluster for identification of HCCs with poor prognosis. Evidence from cell-based assays identifies the existence of a mechanistic link between these two gene clusters, involving the proliferation cluster gene Polo-like kinase 1 (PLK1). We propose that PLK1 is a promising therapy target for HCC.
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