Mycoplasma Bovis adhesins and their target proteins.
Mycoplasma Bovis adhesins and their target proteins.
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牛支原体粘附素及其靶蛋白
DOI：
10.3389/fimmu.2022.1016641
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
牛支原体病是由牛支原体（Mycoplasma bovis，M.牛），这对养殖业构成严重威胁。粘附素参与M.牛的定植与该病原微生物的感染、细胞侵袭、免疫逃逸和毒力密切相关。因为M.牛没有细胞壁，其粘附素主要位于细胞膜表面。M.牛通常通过粘附和粘附抑制分析来鉴定，迄今为止已经鉴定了10多种粘附素。这些粘附素主要与宿主细胞的纤溶酶原、纤连蛋白、肝素和淀粉样蛋白受体样蛋白-2结合。本文就M.牛及其宿主细胞的靶蛋白。此外，粘附素的生物学特性将被简要分析。
Bovine mycoplasmosis is an important infectious disease of cattle caused by Mycoplasma bovis (M. bovis) which poses a serious threat to the breeding industry. Adhesin is involved in the initial process of M. bovis colonization, which is closely related to the infection, cell invasion, immune escape and virulence of this pathogenic microorganism. For the reason that M. bovis lacks a cell wall, its adhesin is predominantly located on the surface of the cell membrane. The adhesins of M. bovis are usually identified by adhesion and adhesion inhibition analysis, and more than 10 adhesins have been identified so far. These adhesins primarily bind to plasminogen, fibronectin, heparin and amyloid precursor-like protein-2 of host cells. This review aims to concisely summarize the current knowledge regarding the adhesins of M. bovis and their target proteins of the host cell. Additionally, the biological characteristics of the adhesin will be briefly analyzed.
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