Factors Associated With Remote Diffusion-Weighted Imaging Lesions in Spontaneous Intracerebral Hemorrhage.
Factors Associated With Remote Diffusion-Weighted Imaging Lesions in Spontaneous Intracerebral Hemorrhage.
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自发性脑出血远程弥散加权成像病变的相关因素
DOI：
10.3389/fneur.2018.00209
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发表时间：
2018
影响因子：
3.4
通讯作者：
Gao F
中科院分区：
文献类型：
--
作者：
Ye XH;Gao T;Xu XH;Cai JS;Li JW;Liu KM;Song SJ;Yin XZ;Tong LS;Gao F
背景和目的自发性脑出血（ICH）患者的远端弥散加权成像（R-DWILs）已被发现，并可能与临床结局相关。然而，R-DWILs的机制和特性尚未完全阐明。在这项研究中，我们试图证明R-DWIL在自发性ICH中的临床特征。方法我们前瞻性收集了2016年11月至2017年12月期间自发性ICH患者的数据。在这些患者中，脑磁共振成像在ICH发作后28天内进行。R-DWIL定义为弥散加权成像中的高信号，表观弥散系数中相应的低信号，并且距离血肿至少20 mm。我们通过单因素和多因素分析比较了两组患者的人口统计学和临床特征、实验室参数和影像学特征。结果222例患者中，41例（18.5%）共观察到75个R-DWIL。病变部位以皮质及皮质下区为主，占77.3%。R-DWIL的中位直径为7 mm（范围2-20 mm）。发现12例患者有一个以上的病变，其中5例在多个脑动脉区域显示R-DWIL。在多变量建模中，空腹血糖较高（OR 1.231; 95% CI 1.035-1.465; p = 0.019）和更严重的白色高信号（WMH）（OR 6.589; 95% CI 2.975-14.592; p < 0.001）是与R-DWIL存在相关的独立因素。结论在我们的研究中，大约五分之一的ICH患者表现出R-DWIL共存。高空腹血糖和更严重的WMH与自发性ICH中R-DWIL的发生相关。
Background and purpose Remote diffusion-weighted imaging lesions (R-DWILs) have been detected in patients with spontaneous intracerebral hemorrhage (ICH) and may be correlated with clinical outcome. However, the mechanisms and characteristics of R-DWILs have not been fully elucidated. In this study, we sought to demonstrate the clinical characteristics of R-DWILs in spontaneous ICH. Methods We prospectively collected data with spontaneous ICH patients from November 2016 to December 2017. In these patients, cerebral magnetic resonance imaging was performed within 28 days after ICH onset. R-DWIL was defined as a hyperintensity signal in diffusion-weighted imaging with corresponding hypointensity in apparent diffusion coefficient, and at least 20 mm apart from the hematoma. We compared two groups of patients with or without R-DWIL with the demographic and clinical characteristics, laboratory parameters, and imaging characteristics, by using univariate and multivariate analysis. Results Of the 222 patients enrolled, a total of 75 R-DWILs were observed in 41 patients (18.5%). Among these lesions, the cortical and subcortical areas were the predominant locations with a proportion of 77.3%. The median diameter of R-DWILs was 7 mm (range 2–20 mm). Twelve patients were found having more than one lesion, with five among which showed R-DWILs in multiple cerebral arterial territories. In multivariate modeling, higher fasting glucose (OR 1.231; 95% CI 1.035–1.465; p = 0.019) and more severe white matter hyperintensity (WMH) (OR 6.589; 95% CI 2.975–14.592; p < 0.001) were independent factors related to the presence of R-DWILs. Conclusion In our study, approximately one-fifth of ICH patients showed coexistence of R-DWIL. Higher fasting glucose and more severe WMH were associated with R-DWIL occurrence in spontaneous ICH.
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影响因子：
11.2
作者：
Menon, Ravi S.;Burgess, Richard E.;Wing, Jeffrey J.;Gibbons, M. Christopher;Shara, Nawar M.;Fernandez, Stephen;Jayam-Trouth, Annapurni;German, Laura;Sobotka, Ian;Edwards, Dorothy;Kidwell, Chelsea S.
通讯作者：
Kidwell, Chelsea S.
影响因子：
11.2
作者：
RINGELSTEIN, EB;KOSCHORKE, S;MINALE, C
通讯作者：
MINALE, C
血压降低，MRI的扩散降低以及脑出血后的结果。
影响因子：
8.3
作者：
Garg RK;Liebling SM;Maas MB;Nemeth AJ;Russell EJ;Naidech AM
通讯作者：
Naidech AM
影响因子：
48
作者：
van Asch, Charlotte J. J.;Luitse, Merel J. A.;Klijn, Catharina J. M.
通讯作者：
Klijn, Catharina J. M.
影响因子：
9.9
作者：
Kimberly, W. T.;Gilson, A.;Greenberg, S. M.
通讯作者：
Greenberg, S. M.