Association of Lean and Fat Body Mass, Bone Biomarkers and Gonadal Steroids with Bone Mass during Pre- and Midpuberty
Association of Lean and Fat Body Mass, Bone Biomarkers and Gonadal Steroids with Bone Mass during Pre- and Midpuberty
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瘦体重和脂肪体重、骨生物标志物和性腺类固醇与青春期前和青春期中期骨量的关联
DOI：
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发表时间：
2012
影响因子：
3.2
通讯作者：
G. Kovacs
中科院分区：
文献类型：
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作者：
V. Csákváry;É. Erhardt;P. Vargha;G. Oroszlán;Tamas Bodecs;Dora Torok;E. Toldy;G. Kovacs
背景/目标：在青春期前和青春期中期，研究了匈牙利儿童的骨量与身体成分、骨转换标志物和性腺类固醇的关系。方法：对237名7 ~ 16岁儿童（56%为女生）进行调查。采用双能X线吸收法（Lunar Prodigy）评估骨矿物质密度（BMD）、脂肪量以及总瘦体重和非总瘦体重。计算脂肪质量指数（fat mass index）和非典型瘦体重指数（approximular lean mass index，LMI）。分析血清骨标志物、甲状旁腺激素、雌二醇和睾酮。多元回归分析评价变量间的相关性。结果：在青春期前，骨生物标志物、性腺类固醇和非性腺性LMI与男女骨量相关（p < 0.05）。在青春期中期，女孩的骨转换标志物与骨量呈负相关（p < 0.001）。在青春期前，approximular LMI和β-crosslaps是两种性别骨量的预测因子。在青春期中期，非性腺LMI和性腺类固醇对两种性别的骨量都有积极的贡献，而骨钙素对女孩的总骨密度和L1-L4脊柱骨密度以及男孩的L1-L4骨密度有负面影响（所有p < 0.001）。结论：骨发育的预测因子因坦纳分期和性别而异。骨量最重要的决定因素是approximalLMI和雌二醇。
Background/Aims: The association of bone mass with body composition, bone turnover markers and gonadal steroids was examined in Hungarian children during pre- and midpuberty. Methods: Two hundred and thirty-seven 7- to 16-year-old subjects (56% girls) were investigated. Bone mineral density (BMD), fat mass and total and appendicular lean mass were estimated with dual-energy X-ray absorptiometry (Lunar Prodigy). The fat mass index and appendicular lean mass index (LMI) were calculated. Serum bone markers, parathyroid hormone, estradiol and testosterone were analyzed. Associations between variables were evaluated by multiple regression analysis. Results: During prepuberty, bone biomarkers, gonadal steroids and appendicular LMI were associated with bone mass in both genders (p < 0.05). During midpuberty, girls’ bone turnover markers were negatively associated with bone mass (p < 0.001). In prepuberty, appendicular LMI and β-crosslaps were predictors of bone mass in both genders. During midpuberty, appendicular LMI and gonadal steroids positively contributed to bone mass in both genders, while osteocalcin exerted a negative influence on total and L1–L4 spine BMD in girls and on L1–L4 BMD in boys (all p < 0.001). Conclusions: Predictors for bone development varied according to Tanner stage and gender. The most significant determinants of bone mass were appendicular LMI and estradiol.
影响因子：
5.8
作者：
Hill, Kathleen M.;Braun, Michelle M.;Weaver, Connie M.
通讯作者：
Weaver, Connie M.