The TNF Superfamily Molecule LIGHT Promotes the Generation of Circulating and Lung-Resident Memory CD8 T Cells following an Acute Respiratory Virus Infection.
The TNF Superfamily Molecule LIGHT Promotes the Generation of Circulating and Lung-Resident Memory CD8 T Cells following an Acute Respiratory Virus Infection.
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DOI：
10.4049/jimmunol.1701499
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发表时间：
2018-04-15
期刊：
影响因子：
--
通讯作者：
Salek-Ardakani S
中科院分区：
文献类型：
--
作者：
Desai P;Tahiliani V;Hutchinson TE;Dastmalchi F;Stanfield J;Abboud G;Thomas PG;Ware CF;Song J;Croft M;Salek-Ardakani S
效应器T细胞或记忆前体细胞向不同的长寿记忆T细胞亚群的转变还不是很清楚。虽然抗原提呈细胞(APC)产生的许多分子可以促进克隆性增殖和效应细胞的分化，但克隆性收缩和记忆发展是被动的还是主动的，目前尚不清楚。利用呼吸道病毒感染，我们发现不能表达肿瘤坏死因子家族分子LIGH的CD8 T细胞在最初的反应中没有受到损害，并克隆地扩张形成效应细胞池。此后，缺乏光的CD8T细胞经历了显著增强的克隆性收缩，从而导致循环和组织驻留记忆细胞的损害积累。效应反应高峰期的光表达调节包括Akt在内的几个促凋亡和抗凋亡基因的平衡，并对外周记忆群体的发育产生优先影响。这些结果强调了光活动在编程记忆CD8 T细胞发育中的重要性，并表明CD8效应T细胞可以通过表达光来决定自己成为记忆细胞的命运。
The transition of effector T cells or memory precursors into distinct long-lived memory T cell subsets is not well understood. While many molecules made by antigen presenting cells (APCs) can contribute to clonal expansion and effector cell differentiation, it is not clear if clonal contraction and memory development is passive or active. Using respiratory virus infection, we found that CD8 T cells that cannot express the TNF family molecule LIGHT are unimpaired in their initial response and clonally expand to form effector cell pools. Thereafter, LIGHT-deficient CD8 T cells undergo strikingly enhanced clonal contraction with resultant compromised accumulation of both circulating and tissue resident memory cells. LIGHT expression at the peak of the effector response regulates the balance of several pro- and anti-apoptotic genes, including Akt, and has a preferential impact on the development of the peripheral memory population. These results underscore the importance of LIGHT activity in programming memory CD8 T cell development, and suggest that CD8 effector T cells can dictate their own fate into becoming memory cells by expressing LIGHT.
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激活表型，而不是中心或效应子内存表型，可预测记忆CD8+ T细胞的回忆功效。
影响因子：
15.3
作者：
Hikono, Hirokazu;Kohlmeier, Jacob E.;Takamura, Shiki;Wittmer, Susan T.;Roberts, Alan D.;Woodland, David L.
通讯作者：
Woodland, David L.
LIGHT信号通路缺陷加剧小鼠鹦鹉热衣原体呼吸道感染
影响因子：
3.8
作者：
Cai, Hengling;Chen, Shenghua;Chen, Lili
通讯作者：
Chen, Lili
影响因子：
32.4
作者：
Gerlach, Carmen;Moseman, E. Ashley;Loughhead, Scott M.;Alvarez, David;Zwijnenburg, Anthonie J.;Waanders, Lisette;Garg, Rohit;de la Torre, Juan C.;von Andrian, Ulrich H.
通讯作者：
von Andrian, Ulrich H.
影响因子：
4.4
作者：
Jenkins, Misty Rayna;Webby, Richard;Turner, Stephen J.
通讯作者：
Turner, Stephen J.
DOI：
10.4049/jimmunol.1400256
发表时间：
2014-06-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Goulding J;Abboud G;Tahiliani V;Desai P;Hutchinson TE;Salek-Ardakani S
通讯作者：
Salek-Ardakani S