The Chemokine Receptor CX3CR1 Defines Three Antigen-Experienced CD8 T Cell Subsets with Distinct Roles in Immune Surveillance and Homeostasis.
The Chemokine Receptor CX3CR1 Defines Three Antigen-Experienced CD8 T Cell Subsets with Distinct Roles in Immune Surveillance and Homeostasis.
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DOI：
10.1016/j.immuni.2016.10.018
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发表时间：
2016-12-20
期刊：
影响因子：
32.4
通讯作者：
von Andrian, Ulrich H.
中科院分区：
文献类型：
--
作者：
Gerlach, Carmen;Moseman, E. Ashley;Loughhead, Scott M.;Alvarez, David;Zwijnenburg, Anthonie J.;Waanders, Lisette;Garg, Rohit;de la Torre, Juan C.;von Andrian, Ulrich H.
感染诱导病原体特异性T细胞分化为不同的效应体（TEff），从而产生记忆（TMem）亚群。这些转变背后的细胞命运决定和谱系关系尚不清楚。在这里，我们发现趋化因子受体CX3CR1识别三个不同的CD8+ TEff和TMem亚群。经典中枢（TCM）和效应记忆（TEM）细胞及其相应的TEff前体分别为CX3CR1 -和CX3CR1高。病毒感染也诱导了一个数值稳定的CX3CR1int亚群，占血源性TMem细胞的约15%。CX3CR1int TMem细胞比其他TMem亚群更频繁地进行稳态分裂，不仅自我更新，而且有助于扩大CX3CR1 - TCM池。TCM和CX3CR1int细胞都归巢于淋巴结，但CX3CR1int细胞，而不是TEM细胞，主要分布于外周组织。由于CX3CR1int TMem细胞具有独特的表型、稳态和迁移特性，我们将这一亚群称为外周记忆（TPM）细胞，并提出TPM细胞主要负责监测非淋巴组织。
Infections induce pathogen-specific T cell differentiation into diverse effectors (TEff) that give rise to memory (TMem) subsets. The cell fate decisions and lineage relationships that underlie these transitions are poorly understood. Here, we found that the chemokine receptor CX3CR1 identifies three distinct CD8+ TEff and TMem subsets. Classical central (TCM) and effector memory (TEM) cells and their corresponding TEff precursors were CX3CR1− and CX3CR1high, respectively. Viral infection also induced a numerically stable CX3CR1int subset that represented ~15% of blood-borne TMem cells. CX3CR1int TMem cells underwent more frequent homeostatic divisions than other TMem subsets and not only self-renewed, but also contributed to the expanding CX3CR1− TCM pool. Both TCM and CX3CR1int cells homed to lymph nodes, but CX3CR1int cells, and not TEM cells, predominantly surveyed peripheral tissues. As CX3CR1int TMem cells present unique phenotypic, homeostatic and migratory properties, we designate this subset peripheral memory (TPM) cells and propose that TPM cells are chiefly responsible for the surveillance of non-lymphoid tissues.
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影响因子：
2.2
作者：
Ionac, M;Laskay, T;Solbach, W
通讯作者：
Solbach, W
激活表型，而不是中心或效应子内存表型，可预测记忆CD8+ T细胞的回忆功效。
影响因子：
15.3
作者：
Hikono, Hirokazu;Kohlmeier, Jacob E.;Takamura, Shiki;Wittmer, Susan T.;Roberts, Alan D.;Woodland, David L.
通讯作者：
Woodland, David L.
DOI：
10.1084/jem.171.3.801
发表时间：
1990-03-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Mackay CR;Marston WL;Dudler L
通讯作者：
Dudler L
影响因子：
30.5
作者：
Kaech, SM;Tan, JT;Ahmed, R
通讯作者：
Ahmed, R
影响因子：
15.9
作者：
Manjunath, N;Shankar, P;von Andrian, UH
通讯作者：
von Andrian, UH