NFE2L2 Is a Potential Prognostic Biomarker and Is Correlated with Immune Infiltration in Brain Lower Grade Glioma: A Pan-Cancer Analysis.
NFE2L2 Is a Potential Prognostic Biomarker and Is Correlated with Immune Infiltration in Brain Lower Grade Glioma: A Pan-Cancer Analysis.
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NFE2L2 是一种潜在的预后生物标志物，与脑低级别胶质瘤的免疫浸润相关：一项泛癌症分析。
DOI：
10.1155/2020/3580719
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发表时间：
2020
影响因子：
--
通讯作者：
Zhao Y
中科院分区：
文献类型：
--
作者：
Ju Q;Li X;Zhang H;Yan S;Li Y;Zhao Y
核因子红细胞2样2（NFE 2L 2，NRF 2）是一种转录因子，调节各种抗氧化酶。它在调节氧化应激和炎症反应中起着重要的生理作用。然而，NFE 2L 2在人类癌症中的作用仍不清楚。本研究旨在分析NFE 2L 2在泛癌中的预后价值，并揭示NFE 2L 2表达与肿瘤免疫的关系。本研究揭示了NFE 2L 2在人类泛癌中的异常表达，并与错配修复（MMR）基因突变水平和DNA甲基转移酶表达显著相关。特别是，泛癌生存分析表明，NFE 2L 2表达与肾上腺皮质癌（ACC）、脑低级别胶质瘤（LGG）和胰腺癌（PAAD）患者的不良结局-总生存期（OS）、疾病特异性生存期（DSS）和无进展间期（PFI）相关。NFE 2 L2表达与免疫浸润呈正相关，免疫浸润包括B细胞、CD 4 + T细胞、CD 8 + T细胞、中性粒细胞、巨噬细胞和树突状细胞，尤其是在乳腺浸润癌（BRCA）、结肠腺癌（COAD）、肾透明细胞癌（KIRC）、LGG、肝细胞癌（LIHC）和前列腺癌（PRAD）中。此外，NFE 2L 2表达与免疫评分和LGG中免疫检查点标记物的表达呈正相关。总之，这些结果表明，转录因子NFE 2L 2是一种潜在的预后生物标志物，并与LGG中的免疫浸润相关。
Nuclear factor, erythroid 2 like 2 (NFE2L2, NRF2) is a transcription factor that regulates various antioxidant enzymes. It plays a vital physiological role in regulating oxidative stress and inflammatory response. However, the roles of NFE2L2 in human cancers are still unclear. Our study is aimed at analyzing the prognostic value of NFE2L2 in pan-cancer and at revealing the relationship between NFE2L2 expression and tumor immunity. The present study revealed that NFE2L2 was abnormally expressed and significantly correlated with mismatch repair (MMR) gene mutation levels and DNA methyltransferase expression in human pan-cancer. In particular, pan-cancer survival analysis indicated that NFE2L2 expression was associated with adverse outcomes—overall survival (OS), disease-specific survival (DSS), and progression-free interval (PFI)—in adrenocortical carcinoma (ACC), brain lower grade glioma (LGG), and pancreatic adenocarcinoma (PAAD) patients. A positive relationship was also found between NFE2L2 expression and immune infiltration, including B cells, CD4+ T cells, CD8+ T cells, neutrophils, macrophages, and dendritic cells, especially in breast invasive carcinoma (BRCA), colon adenocarcinoma (COAD), kidney renal clear cell carcinoma (KIRC), LGG, liver hepatocellular carcinoma (LIHC), and prostate adenocarcinoma (PRAD). Additionally, NFE2L2 expression was positively correlated with the immune score and the expression of immune checkpoint markers in LGG. In conclusion, these results indicate that transcription factor NFE2L2 is a potential prognostic biomarker and is correlated with immune infiltration in LGG.
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作者：
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