Recent Advances of Autophagy in Non-Small Cell Lung Cancer: From Basic Mechanisms to Clinical Application.
Recent Advances of Autophagy in Non-Small Cell Lung Cancer: From Basic Mechanisms to Clinical Application.
复制标题
DOI：
10.3389/fonc.2022.861959
复制
发表时间：
2022
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
肺癌是世界范围内最常见的肿瘤疾病和癌症死亡的主要原因，其中一组亚型称为非小细胞肺癌（NSCLC）约占85%。在过去的几十年里，非小细胞肺癌治疗的重要进展增强了我们对肿瘤生物学和进展机制的认识。免疫疗法和小分子酪氨酸激酶抑制剂的应用为某些患者带来了显著的临床益处。然而，早期转移和抗肿瘤治疗的出现导致NSCLC的总治愈率和生存率相对较低。自噬是一种保守的过程，它允许细胞回收未使用或受损的细胞器和细胞成分。据报道，它与NSCLC的进展和对靶向治疗和细胞毒性化疗的耐药性有关。因此，自噬被认为是治疗非小细胞肺癌的潜在靶点。在非小细胞肺癌模型中，酪氨酸激酶抑制剂和自噬抑制剂联合使用的研究结果越来越多。本文旨在全面综述自噬在非小细胞肺癌中的作用，重点介绍调节非小细胞肺癌自噬的药物的相关临床资料。此外，本研究将为进一步完善基于自噬的癌症治疗提供理论依据。
Lung cancer is characterized by the most common oncological disease and leading cause of cancer death worldwide, of which a group of subtypes known as non-small cell lung cancer (NSCLC) accounts for approximately 85%. In the past few decades, important progression in the therapies of NSCLC has enhanced our understanding of the biology and progression mechanisms of tumor. The application of immunotherapy and small molecule tyrosine kinase inhibitors has brought significant clinical benefits in certain patients. However, early metastasis and the emergence of resistance to antitumor therapy have resulted in the relatively low overall cure and survival rates for NSCLC. Autophagy is a conserved process that allows cells to recycle unused or damaged organelles and cellular components. It has been reported to be related to the progression of NSCLC and resistance to targeted therapy and cytotoxic chemotherapy. Therefore, autophagy is considered as a potential therapeutic target for NSCLC. Mounting results have been reported about the combination of tyrosine kinase inhibitors and inhibitors of autophagy in models of NSCLC. This review aims to provide a comprehensive review on the roles of autophagy in NSCLC, focusing on related clinical data of agents that regulate autophagy in NSCLC. Furthermore, this study will provide a theoretical basis for further improvement of autophagy-based cancer therapy.
登录
查看更多内容
影响因子：
4.7
作者：
Bustos SO;Antunes F;Rangel MC;Chammas R
通讯作者：
Chammas R
氯喹通过将肿瘤相关巨噬细胞重置为 M1 表型来调节抗肿瘤免疫反应
影响因子：
16.6
作者：
Chen D;Xie J;Fiskesund R;Dong W;Liang X;Lv J;Jin X;Liu J;Mo S;Zhang T;Cheng F;Zhou Y;Zhang H;Tang K;Ma J;Liu Y;Huang B
通讯作者：
Huang B
影响因子：
10.5
作者：
Guo, Jessie Yanxiang;Chen, Hsin-Yi;White, Eileen
通讯作者：
White, Eileen
DOI：
10.1073/pnas.1815345116
发表时间：
2019-01-02
影响因子：
11.1
作者：
Bocci, Federico;Gearhart-Serna, Larisa;Jolly, Mohit Kumar
通讯作者：
Jolly, Mohit Kumar
DOI：
10.1097/jto.0b013e318262de4a
发表时间：
2012-10
期刊：
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
影响因子：
--
作者：
Goldberg SB;Supko JG;Neal JW;Muzikansky A;Digumarthy S;Fidias P;Temel JS;Heist RS;Shaw AT;McCarthy PO;Lynch TJ;Sharma S;Settleman JE;Sequist LV
通讯作者：
Sequist LV