Dimensional endophenotypes in bipolar disorder: affective dysregulation and psychosis proneness.
Dimensional endophenotypes in bipolar disorder: affective dysregulation and psychosis proneness.
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双相情感障碍的维度内表型：情感失调和精神病倾向。
DOI：
10.1016/j.jad.2013.08.003
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发表时间：
2013
影响因子：
6.6
通讯作者：
Burdick,KE
中科院分区：
文献类型：
--
作者：
Mahon,K;Perez-Rodriguez,MM;Gunawardane,N;Burdick,KE
背景双相情感障碍（BPD）的临床表型具有异质性，其遗传结构复杂，目前尚不清楚。考虑到这些并发症，鉴定中间表型（“内表型”）可能有助于阐明导致该疾病的复杂遗传机制。对未受影响的亲属的检查对于确定特定性状是否与BPD遗传相关至关重要。然而，一些尺寸性状相关的BPD已被评估在未受影响的亲属patients.MethodsWe评估情感气质和情感型在55个不和谐的兄弟姐妹对和113个健康对照（HC）使用气质评价的孟菲斯，比萨，巴黎，和圣地亚哥，自动问卷版本（TEMPS-A）评估情感气质和分裂型人格问卷（SPQ）结果BPD患者在SPQ的所有分量表和TEMPS-A的除一个分量表（情绪亢进）外的所有分量表上的得分均显著高于HC（p <0. 01）。SIEMENS表现出的评分是显着中间的病人和HC的焦虑子量表的TEMPS-A和人际关系的赤字和混乱的子量表的SPQ.LimitationsWe没有调查的BPD谱，因为大多数患者被诊断为BPD I（n=47）。大多数患者都经历过精神病（n=42），所以我们无法检查是否精神病状态影响情感气质或anodotypy的患者或他们的siblings.ConclusionThese数据表明，anodotypy和情感气质的维度特征，可能是潜在的遗传风险BPD。
BackgroundThe clinical phenotype of bipolar disorder (BPD) is heterogeneous and the genetic architecture of the disorder is complex and not well understood. Given these complications, it is possible that the identification of intermediate phenotypes (“endophenotypes”) will be useful in elucidating the complex genetic mechanisms that result in the disorder. The examination of unaffected relatives is critical in determining whether a particular trait is genetically-relevant to BPD. However, few dimensional traits related to BPD have been assessed in unaffected relatives of patients.MethodsWe assessed affective temperament and schizotypy in 55 discordant sibling pairs and 113 healthy controls (HCs) using the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego, Auto-questionnaire version (TEMPS-A) to assess affective temperament and the Schizotypal Personality Questionnaire (SPQ) to assess schizotypy.ResultsBPD patients scored significantly higher than HCs on all subscales of the SPQ and on all but one subscale (hyperthymic) of the TEMPS-A (allp<0.01). Siblings demonstrated scores that were significantly intermediate to patients and HCs on the anxious subscale of the TEMPS-A and on the interpersonal deficits and disorganized subscales of the SPQ.LimitationsWe did not investigate the BPD spectrum as most patients were diagnosed with BPD I (n=47). Most of the patients had experienced psychosis (n=42) and so we were unable to examine whether psychosis status impacted upon affective temperament or schizotypy in patients or their siblings.ConclusionThese data suggest that schizotypy and affective temperament represent dimensional traits that are likely to underlie the genetic risk for BPD.
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影响因子：
6.6
作者：
Ferriera, Alexandre de Aguiar;Vasconcelos, Alina Gomide;Correa, Humberto
通讯作者：
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影响因子：
6.6
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影响因子：
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作者：
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影响因子：
10.5
作者：
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J. Savitz;L. van der Merwe;D. Stein;M. Solms;R. Ramesar
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影响因子：
6.6
作者：
J. Savitz;L. van der Merwe;R. Ramesar
通讯作者：
R. Ramesar