The mobile receptor hypothesis and "cooperativity" of hormone binding. Application to insulin.
The mobile receptor hypothesis and "cooperativity" of hormone binding. Application to insulin.
复制标题
移动受体假说和激素结合的“协同性”。
DOI：
10.1016/0005-2736(76)90275-3
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
P. Cuatrecasas
中科院分区：
文献类型：
--
作者：
S. Jacobs;P. Cuatrecasas
移动的受体假说被提出来描述激素受体结合引发生物反应的过程;它指出受体可以在膜平面上独立扩散，可逆地与效应物结合以调节其活性。利用移动的受体假说的数学表达式表明：（1）激素受体结合的动力学可能与“负协同效应”没有区别。(2)受体结合和生物学反应可能以非线性的方式耦合，通过选择特定的参数，大多数关于胰岛素结合和生物学反应的现有数据可以用移动的受体假说来解释。因此，以下是很容易解释的：（1）一个单一的同质受体可能出现在动力学上由两类（高和低亲和力）受体组成。(2)高亲和力受体的表观类别的占有率与生物学反应线性相关。(3)不同组织中的相同受体可能表现出不同的亲和力。(4)不同生物活性胰岛素类似物的结合可能表现出不同程度的“协同”。这些考虑也可能与其他激素-受体系统和各种配体-大分子相互作用的解释有关。
The mobile receptor hypothesis has been proposed to describe the process by which hormone receptor binding initiates a biological response; it states that receptors, which can diffuse independently in the plane of the membrane, reversibly associate with effectors to regulate their activity. The affinity for effector is greater when the receptor is occupied by hormone.A mathematical expression of the mobile receptor hypothesis is used to show that: (1) The predicted kinetics of hormone receptor binding may be indistinguishable from “negative cooperativity”. (2) Receptor occupancy and biological response may be coupled in a non-linear fashion.By choosing specific parameters, most of the existing data on insulin binding and biological responses can be explained in terms of the mobile receptor hypothesis. Thus, the following are easily explained: (1) A single homogeneous receptor may appear kinetically to be composed of two classes (of high and low affinity) of receptors. (2) Occupancy of the apparent class of high affinity receptors is related linearly to the biological response. (3) The same receptor in different tissues may appear to have different affinity. (4) The binding of different biologically active insulin analogues may exhibit different degrees of “cooperatively.” These considerations may also be pertinent to intepretations of other hormone-receptor systems and of various ligand-macromolecule interactions.
肾上腺切除术诱导的大脑生长的位点特异性。
影响因子：
5.3
作者：
Thomas,TL;Devenport,LD
通讯作者：
Devenport,LD