Targeting gastrointestinal cancers with chimeric antigen receptor (CAR)-T cell therapy.
Targeting gastrointestinal cancers with chimeric antigen receptor (CAR)-T cell therapy.
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DOI：
10.1080/15384047.2022.2033057
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发表时间：
2022-12-31
影响因子：
3.6
通讯作者：
Snook AE
中科院分区：
文献类型：
--
作者：
Staudt RE;Carlson RD;Snook AE
免疫系统能够对传染病具有非常有效和特异的功效。几十年来，研究人员试图利用这些特征来创造基于免疫的疗法（免疫疗法），这种疗法可能比传统的癌症化疗和放射疗法更有效且毒性更小。这些研究揭示了癌症免疫疗法成功或失败的许多因素和机制，从而催生了包括 CAR-T 细胞疗法在内的合成生物学方法。在这种方法中，患者的 T 细胞经过基因改造，表达嵌合抗原受体 (CAR)，将任何特异性的 T 细胞转化为肿瘤特异性 T 细胞，这些 T 细胞可以大量扩增并重新注射给患者以消除癌细胞，包括大量转移性疾病。这种方法在治疗血液癌症方面最为成功，迄今为止已获得 FDA 5 项批准。在这里，我们讨论将该技术应用于胃肠道癌症的一些最有希望的尝试。
The immune system is capable of remarkably potent and specific efficacy against infectious diseases. For decades, investigators sought to leverage those characteristics to create immune-based therapies (immunotherapy) that might be far more effective and less toxic than conventional chemotherapy and radiation therapy for cancer. Those studies revealed many factors and mechanisms underlying the success or failure of cancer immunotherapy, leading to synthetic biology approaches, including CAR-T cell therapy. In this approach, patient T cells are genetically modified to express a chimeric antigen receptor (CAR) that converts T cells of any specificity into tumor-specific T cells that can be expanded to large numbers and readministered to the patient to eliminate cancer cells, including bulky metastatic disease. This approach has been most successful against hematologic cancers, resulting in five FDA approvals to date. Here, we discuss some of the most promising attempts to apply this technology to cancers of the gastrointestinal tract.
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影响因子：
4.4
作者：
Aka AA;Rappaport JA;Pattison AM;Sato T;Snook AE;Waldman SA
通讯作者：
Waldman SA
影响因子：
7.3
作者：
Decker WK;da Silva RF;Sanabria MH;Angelo LS;Guimarães F;Burt BM;Kheradmand F;Paust S
通讯作者：
Paust S
影响因子：
--
作者：
Marszalowicz GP;Snook AE;Magee MS;Merlino D;Berman-Booty LD;Waldman SA
通讯作者：
Waldman SA
影响因子：
6.7
作者：
BURNET, M
通讯作者：
BURNET, M
DOI：
10.1158/1078-0432.ccr-20-2584
发表时间：
2021-03-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Kontos F;Michelakos T;Kurokawa T;Sadagopan A;Schwab JH;Ferrone CR;Ferrone S
通讯作者：
Ferrone S