Regulation of Wnt/β-catenin signaling within and from osteocytes.
Regulation of Wnt/β-catenin signaling within and from osteocytes.
复制标题
DOI：
10.1016/j.bone.2013.02.022
复制
发表时间：
2013-06
期刊：
影响因子：
4.1
通讯作者：
Williams, Bart O.
中科院分区：
文献类型：
--
作者：
Burgers, Travis A.;Williams, Bart O.
长期以来人们都知道骨骼对机械负荷有反应。至少 25 年来，人们就知道骨细胞能够感知机械载荷，并且由于它们对机械载荷的反应，骨细胞被认为是机械感觉细胞。 Wnt/β-catenin 信号通路已被证明在骨骼发育中至关重要。 LRP5 和 SOST 的突变会导致高骨量，这增加了人们对 Wnt 通路作为骨质疏松症治疗潜在靶点的兴趣，并有助于将 Wnt/β-连环蛋白信号传导与骨骼对机械负荷的反应联系起来。由于其对骨细胞的特异性，Wnt 抑制剂硬化素是合成代谢骨疗法的靶标。骨骼对机械负荷的反应受到分泌硬化蛋白（与 Lrp5 结合）的骨细胞的严格调节。
Bone has long been known to be responsive to mechanical loading. For at least 25 years it has been known that osteocytes sense mechanical load, and because of their response to mechanical loading, osteocytes are believed to be the mechanosensory cell. The Wnt/β-catenin signaling pathway has been shown to be crucial in bone development. Mutations in LRP5 and SOST, which cause high bone mass, have increased interest in the Wnt pathway as a potential target for osteoporosis therapy and have helped link Wnt/β-catenin signaling to bone’s response to mechanical loading. Because of its specificity to osteocytes, the Wnt inhibitor sclerostin is a target for anabolic bone therapies. The response of bone to mechanical loading is critically regulated by osteocytes secreting sclerostin, which binds to Lrp5.
登录
查看更多内容
影响因子：
4.8
作者：
Bafico, A;Gazit, A;Aaronson, SA
通讯作者：
Aaronson, SA
影响因子：
3
作者：
Gluhak-Heinrich, J.;Pavlin, D.;Harris, S. E.
通讯作者：
Harris, S. E.
影响因子：
4.2
作者：
Balemans, Wendy;Piters, Elke;Van Hul, Wim
通讯作者：
Van Hul, Wim
影响因子：
4.8
作者：
Cherian, PP;Cheng, BX;Jiang, JX
通讯作者：
Jiang, JX
影响因子：
82.9
作者：
通讯作者：
--