Cardiac computed tomography-derived extracellular volume fraction in late anthracycline-induced cardiotoxicity.

Cardiac computed tomography-derived extracellular volume fraction in late anthracycline-induced cardiotoxicity.
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晚期蒽环类药物引起心脏毒性的心脏计算机断层成像细胞外容积分数。

DOI:
10.1016/j.ijcha.2021.100797
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发表时间:
2021-06
期刊:
International journal of cardiology. Heart & vasculature
影响因子:
--
通讯作者:
Tsujita K
Tsujita K
中科院分区:
其他
文献类型:
--
作者:
Egashira K;Sueta D;Tomiguchi M;Kidoh M;Oda S;Usuku H;Hidaka K;Goto-Yamaguchi L;Sueta A;Komorita T;Takae M;Oike F;Fujisue K;Yamamoto E;Hanatani S;Takashio S;Arima Y;Araki S;Kaikita K;Matsushita K;Yamamoto Y;Hirai T;Tsujita K

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蒽环类药物给药后晚期的心脏毒性仍有待确定。在接受蒽环类药物治疗的 44 名患者中,7 名被发现患有癌症治疗相关心功能障碍 (CTRCD)。 CTRCD(+)组超声心动图测定的整体纵向应变和心脏计算机断层扫描(CCT)测定的心肌细胞外体积分数(ECV)均显着高于对照组和CTRCD(-)组,而对照组和CTRCD(-)组之间无显着性差异。我们的研究结果表明,CCT 可能是与超声心动图相当的工具,表明 CCT 可以有效评估 CTRCD。
Cardiotoxicity in the late phase after anthracycline drugs administration remains to be defined. Of the 44 patients who received anthracycline treatment, 7 were found to have cancer therapeutics–related cardiac dysfunction (CTRCD). The global longitudinal strain determined by echocardiography and myocardial extracellular volume fraction (ECV) determined by cardiac computed tomography (CCT) of the CTRCD(+) group were significantly higher than those of the control group and CTRCD(-) group, whereas there were no significant differences between the control and CTRCD(-) groups. Our findings indicated that CCT may be a tool comparable to echocardiography, indicating the effective evaluation of CTRCD by CCT.
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