Repetitive stress in mice causes migraine-like behaviors and calcitonin gene-related peptide-dependent hyperalgesic priming to a migraine trigger.
Repetitive stress in mice causes migraine-like behaviors and calcitonin gene-related peptide-dependent hyperalgesic priming to a migraine trigger.
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DOI：
10.1097/j.pain.0000000000001953
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发表时间：
2020-11
期刊：
影响因子：
7.4
通讯作者：
Dussor G
中科院分区：
文献类型：
--
作者：
Avona A;Mason BN;Lackovic J;Wajahat N;Motina M;Quigley L;Burgos-Vega C;Moldovan Loomis C;Garcia-Martinez LF;Akopian AN;Price TJ;Dussor G
偏头痛是全球第二大致残性疾病[27]，其特征为单侧搏动性疼痛、皮肤异常性疼痛，通常伴有恶心和对光和声音敏感。发作可能由触发因素引起，包括激素或睡眠模式的变化，不吃饭，饮酒和某些食物[32]。暴露于这些常见事件后对攻击的易感性表明，在偏头痛相关的伤害性通路中发生了适应不良的变化。偏头痛最常见的触发因素是压力[32]，它可以增加头痛的持续时间[57]，并可能在慢性头痛疾病的发展中发挥作用[50]。发作通常不会在压力持续时发生，而是在压力事件过去后[53; 54]，在压力消退后6至18小时最易发生[38]。此外，多日的强烈压力比一天更容易引发发作[38]。尽管压力和偏头痛之间有密切的关系，但两者之间的机制联系仍然知之甚少。临床前偏头痛研究使用的压力方法包括约束，强光，不可预测的声音，潮湿的床上用品，暴露于捕食者，或压力源的组合。急性或慢性应激降低皮质扩散性抑制（CSD）的阈值[6; 58]，增加一氧化氮合酶表达[59]，改变硬脑膜中的免疫细胞特性[44; 45]，并调节三叉神经尾侧核的下丘脑调节[48]。在行为上，束缚应激增加了大鼠对高剂量（10 mg/kg）一氧化氮（NO）供体硝酸甘油（NTG）的甩尾反应[17]，并增加了家庭偏瘫性偏头痛小鼠模型中的眨眼和眨眼行为[15]。此外，14天的社交失败应激暴露和40天的慢性可变应激方案引起焦虑样反应、后爪过敏和对高剂量NTG的反应增加
Migraine is the second-most disabling disease worldwide [27], characterized by unilateral throbbing pain, cutaneous allodynia, often accompanied by nausea and sensitivity to light and sound. Attacks can be caused by triggers that include changes in hormones or sleep patterns, skipping meals, consumption of alcohol and certain foods [32]. Susceptibility to attacks following exposure to these common events suggests maladaptive changes have occurred within migraine-related nociceptive pathways. The most commonly-reported trigger for migraine is stress [32], which can increase the duration of headache [57] and may play a role in the development of chronic headache disorders [50]. Attacks often do not occur while stress is ongoing, but rather once the stressful event has passed [53; 54] with greatest susceptibility 6 to 18 hours following resolution of stress [38]. Additionally, multiple days of intense stress are more likely to trigger attacks than a single day [38]. Despite the close correlation between stress and migraine, mechanistic links between the two remain poorly understood.Preclinical migraine studies have used methods of stress including restraint, bright light, unpredictable sounds, wet bedding, exposure to predators, or a combination of stressors. Acute or chronic stress decreases the threshold for cortical-spreading depression (CSD)[6; 58], increases nitric-oxide synthase expression [59], alters immune cell properties in the dura [44; 45], and regulates hypothalamic modulation of the trigeminal nucleus caudalis [48]. Behaviorally, restraint stress increases rat tail-flick responses to high-doses (10 mg/kg) of the nitric oxide (NO) donor nitroglycerin (NTG)[17] and increases eye blinking and shuddering behavior in a mouse model of familial-hemiplegic migraine [15]. Additionally, a 14-day social-defeat stress exposure and 40-day chronic-variable stress protocol caused anxiety-like responses, hindpaw hypersensitivity, and increased responses to high-dose NTG
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DOI：
10.1016/s1474-4422(17)30299-5
发表时间：
2017-11
期刊：
The Lancet. Neurology
影响因子：
--
作者：
GBD 2015 Neurological Disorders Collaborator Group
通讯作者：
GBD 2015 Neurological Disorders Collaborator Group
影响因子：
48
作者：
Dodick, David W.;Goadsby, Peter J.;Grayzel, David S.
通讯作者：
Grayzel, David S.
影响因子：
7.4
作者：
Chanda, Mona Lisa;Tuttle, Alexander H.;Mogil, Jeffrey S.
通讯作者：
Mogil, Jeffrey S.
影响因子：
14.5
作者：
De Felice, Milena;Ossipov, Michael H.;Porreca, Frank
通讯作者：
Porreca, Frank
DOI：
10.1016/j.ynpai.2017.10.001
发表时间：
2017-08
期刊：
Neurobiology of pain (Cambridge, Mass.)
影响因子：
--
作者：
Akintola T;Raver C;Studlack P;Uddin O;Masri R;Keller A
通讯作者：
Keller A