Precore mutation of hepatitis B virus may contribute to hepatocellular carcinoma risk: evidence from an updated meta-analysis.
Precore mutation of hepatitis B virus may contribute to hepatocellular carcinoma risk: evidence from an updated meta-analysis.
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乙型肝炎病毒的核心突变可能会增加肝细胞癌的风险：来自更新的荟萃分析的证据。
DOI：
10.1371/journal.pone.0038394
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Wang L
中科院分区：
文献类型：
--
作者：
Liao Y;Hu X;Chen J;Cai B;Tang J;Ying B;Wang H;Wang L
B肝炎病毒（HepatitisB Virus，HBV）基因组中的前S区突变、基底核心启动子（BasalCoreprotator，BCP）、增强子Ⅱ（EnhII）等突变，尤其是前C区突变与肝细胞癌（HepatocellularCarcinoma，HCC）发生的关系一直备受争议。随着近年来这一领域研究的不断增多，我们进行了这项荟萃分析来评估相关性。我们检索了常用的数据库，包括英文和中文，检索截止日期为2012年2月1日。使用STATA 10.0在固定/随机效应模型中进行荟萃分析。通过Egger检验和Begg漏斗图检验发表偏倚。共纳入85项病例对照研究，涉及16745例HBV感染患者，其中5781例患有HCC。在前C区突变G1896 A（OR = 1.46，95%置信区间[CI]= 1.15-1.85，POR = 0.002）、G1899 A（OR = 3.13，95%CI = 2.38-4.13，POR<0.001）和Pre-S突变，尤其是Pre-S1缺失（OR = 2.94，95%CI = 2.22 - 3.89）和Pre-S2缺失（OR = 3.02，95%CI = 2.03 - 4.50）中观察到统计学显著相关性。 BCP双突变A1762 T/G1764 A、T1753 V、C1653 T与肝癌的发生有相似的相关性。在亚组分析中，亚洲人、C基因型或HBeAg阳性的患者中，携带上述某些突变的患者可能更易患HCC。此外，G1896 A和BCP双突变可能与肝脏疾病的进展有关。前C区G1896 A、G1899 A突变、前S区缺失以及其他常见突变与HCC发病风险增加相关，尤其是在亚洲人群中，并可能预测肝病的进展。
Studies focused on the correlation of mutations in the genome of Hepatitis B Virus (HBV) like Pre-S mutation, Basal Core promoter (BCP), Enhancer II (EnhII), especially Precore mutation, with the risk of hepatocellular carcinoma (HCC) have triggered stiff controversies. With an increasing number of studies in this field recently, we conducted this meta-analysis to appraise the correlations. We searched the commonly used databases both in English and Chinese till February 1st, 2012. Meta-analysis was performed in fixed/random-effects models using STATA 10.0. Publication bias was examined through Egger's test and Begg's funnel plot. In total, 85 case-control studies were included involving 16745 HBV-infected patients, of whom 5781 had HCC. Statistically significant correlations were observed in Precore mutation G1896A (OR = 1.46, 95% confidence interval [CI] = 1.15–1.85, POR = 0.002), G1899A (OR = 3.13, 95%CI = 2.38–4.13, POR<0.001) and Pre-S mutation especially Pre-S1 deletion (OR = 2.94, 95%CI = 2.22 to 3.89) and Pre-S2 deletion (OR = 3.02, 95%CI = 2.03 to 4.50). Similar correlation existed between BCP double mutation A1762T/G1764A, T1753V, C1653T and HCC. In subgroup analysis, the Asians, genotype C or HBeAg positive patients with certain above mutations may be more susceptible to HCC. Besides, the mutations like G1896A and BCP double mutation may be associated with the progression of the liver diseases. Precore mutation G1896A, G1899A, deletions in Pre-S region as well as the other commonly seen mutations correlated with the increased risk of HCC, especially in Asians and may predict the progression of the liver disease.
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影响因子：
15.8
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
6.4
作者：
Chen, Chien-Hung;Changchien, Chi-Sin;Lu, Sheng-Nan
通讯作者：
Lu, Sheng-Nan
影响因子：
12.6
作者：
Chan, Henry Lik-Yuen;Wong, Grace Lai-Hung;Wong, Vincent Wai-Sun
通讯作者：
Wong, Vincent Wai-Sun
影响因子：
2.5
作者：
Jang, J. W.;Lee, Y. C.;Yoon, S. K.
通讯作者：
Yoon, S. K.
DOI：
10.1111/j.1440-1746.2008.05321.x
发表时间：
2008-03-01
影响因子：
4.1
作者：
Elkady, Abeer;Tanaka, Yasuhito;Mizokami, Masashi
通讯作者：
Mizokami, Masashi