Resting-state functional connectivity as a marker of disease progression in Parkinson's disease: A longitudinal MEG study.
Resting-state functional connectivity as a marker of disease progression in Parkinson's disease: A longitudinal MEG study.
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DOI：
10.1016/j.nicl.2013.04.003
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发表时间：
2013
影响因子：
4.2
通讯作者：
Berendse, Henk W.
中科院分区：
文献类型：
--
作者：
Dubbelink, Kim T. E. Olde;Stoffers, Diederick;Deijen, Jan Berend;Twisk, Jos W. R.;Stam, Cornelis J.;Hillebrand, Arjan;Berendse, Henk W.
关键词：
静息态功能连接的评估已成为研究脑疾病机制的重要工具。在这里，我们使用脑磁图纵向评估功能连接的变化与帕金森病（PD）的疾病进展的临床措施。使用源空间为基础的方法与详细的解剖映射，功能连接进行了评估的颞，前额和高阶感觉联合区已知显示神经病理学变化的早期临床疾病阶段。在基线、早期阶段，与对照组相比，未经治疗的PD患者（n = 12）的海马旁和颞叶δ带连接性较低，颞叶α 1带连接性较高。在一个更大的患者组（n = 43）中进行的4年纵向分析显示，与运动或认知恶化相关的多个种子区域的α 1和α 2带连接性降低。在PD的最早临床阶段，δ和α 1带静息态功能连接在颞叶皮质区域发生改变。随着疾病的进展，α 1的初始变化逆转，α 2带连接性进一步降低，并在更广泛的皮质模式中演变。这些功能连接的变化似乎反映了临床相关现象，因此有望作为疾病进展的标志物，对临床结局具有潜在的预测价值。我们使用MEG纵向评估静息状态功能连接在PD。我们报告在早期PD的δ和α 1带连接的改变。这些变化随着病程的发展与临床恶化有关。连接性变化有望成为PD疾病进展的标志。它们也可能对临床结果具有潜在的预测价值。
The assessment of resting-state functional connectivity has become an important tool in studying brain disease mechanisms. Here we use magnetoencephalography to longitudinally evaluate functional connectivity changes in relation to clinical measures of disease progression in Parkinson's disease (PD). Using a source-space based approach with detailed anatomical mapping, functional connectivity was assessed for temporal, prefrontal and high order sensory association areas known to show neuropathological changes in early clinical disease stages. At baseline, early stage, untreated PD patients (n = 12) had lower parahippocampal and temporal delta band connectivity and higher temporal alpha1 band connectivity compared to controls. Longitudinal analyses over a 4-year period in a larger patient group (n = 43) revealed decreases in alpha1 and alpha2 band connectivity for multiple seed regions that were associated with motor or cognitive deterioration. In the earliest clinical stages of PD, delta and alpha1 band resting-state functional connectivity is altered in temporal cortical regions. With disease progression, a reversal of the initial changes in alpha1 and additional decreases in alpha2 band connectivity evolving in a more widespread cortical pattern. These changes in functional connectivity appear to reflect clinically relevant phenomena and therefore hold promise as a marker of disease progression, with potential predictive value for clinical outcome. We use MEG to longitudinally evaluate resting-state functional connectivity in PD. We report alterations in delta and alpha1 band connectivity in early-stage PD. These changes evolve over the disease course in relation to clinical deterioration. Connectivity changes hold promise as a marker of disease progression in PD. They may also have potential predictive value for clinical outcome.
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影响因子：
4.3
作者：
de Haan W;Mott K;van Straaten EC;Scheltens P;Stam CJ
通讯作者：
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通讯作者：
Klimesch, W