Functional disconnection and compensation in mild cognitive impairment: evidence from DLPFC connectivity using resting-state fMRI.
Functional disconnection and compensation in mild cognitive impairment: evidence from DLPFC connectivity using resting-state fMRI.
复制标题
轻度认知障碍的功能断开和补偿：使用静止状态fMRI的DLPFC连通性证据。
DOI：
10.1371/journal.pone.0022153
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Li K
中科院分区：
文献类型：
--
作者：
Liang P;Wang Z;Yang Y;Jia X;Li K
背外侧前额叶皮层（DLPFC）的区域异常及其在轻度认知障碍（MCI）的神经回路中的作用，使其在研究MCI相关的分离中的重要性凸显出来。本研究的目的是检查MCI患者休息时DLPFC功能连接模式以及区域灰质（GM）萎缩对功能结果的影响。收集了14例MCI患者和14名年龄、性别匹配的健康对照者的结构和功能MRI数据。我们发现，双侧DLPFC与顶下小叶（IPL）、上级/内侧额回和皮质下区域（例如，丘脑，壳核）的MCI患者相比，健康对照组。此外，DLPFC与IPL和丘脑的连通性与患者的认知表现显著相关，如通过简易精神状态检查（MMSE）、画钟测试（CDT）和加州言语学习测试（CVLT）评分测量的。当将GM萎缩作为协变量时，这些结果与未校正的结果大致一致，尽管统计功效可能降低。这些结果表明，DLPFC的断开可能是MCI患者认知功能障碍的基础。此外，我们还发现MCI患者左侧DLPFC和右侧前额叶皮质之间的功能连接增强。这与认知任务期间MCI相关激活增加的先前发现一致，并且可能代表MCI患者的代偿机制。总之，本研究使用DLPFC功能连接分析证明MCI患者中功能断开和补偿共存，从而可能提供对疾病的生物学机制的见解。
The known regional abnormality of the dorsolateral prefrontal cortex (DLPFC) and its role in various neural circuits in mild cognitive impairment (MCI) has given prominence to its importance in studies on the disconnection associated with MCI. The purpose of the current study was to examine the DLPFC functional connectivity patterns during rest in MCI patients and the impact of regional grey matter (GM) atrophy on the functional results. Structural and functional MRI data were collected from 14 MCI patients and 14 age, gender-matched healthy controls. We found that both the bilateral DLPFC showed reduced functional connectivity with the inferior parietal lobule (IPL), superior/medial frontal gyrus and sub-cortical regions (e.g., thalamus, putamen) in MCI patients when compared with healthy controls. Moreover, the DLPFC connectivity with the IPL and thalamus significantly correlated with the cognitive performance of patients as measured by mini-mental state examination (MMSE), clock drawing test (CDT), and California verbal learning test (CVLT) scores. When taking GM atrophy as covariates, these results were approximately consistent with those without correction, although there may be a decrease in the statistical power. These results suggest that the DLPFC disconnections may be the substrates of cognitive impairments in MCI patients. In addition, we also found enhanced functional connectivity between the left DLPFC and the right prefrontal cortex in MCI patients. This is consistent with previous findings of MCI-related increased activation during cognitive tasks, and may represent a compensatory mechanism in MCI patients. Together, the present study demonstrated the coexistence of functional disconnection and compensation in MCI patients using DLPFC functional connectivity analysis, and thus might provide insights into biological mechanism of the disease.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
4.8
作者：
Hampson, M;Peterson, BS;Gore, JC
通讯作者：
Gore, JC
影响因子：
5.7
作者：
Baron, JC;Chételat, G;Eustache, F
通讯作者：
Eustache, F
影响因子：
3.5
作者：
Bahar-Fuchs, Alex;Moss, Simon;Savage, Greg
通讯作者：
Savage, Greg
影响因子：
5.3
作者：
Grady, CL;McIntosh, AR;Black, SE
通讯作者：
Black, SE