A progressive declining in the burden of malaria in north-eastern Tanzania.
A progressive declining in the burden of malaria in north-eastern Tanzania.
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DOI：
10.1186/1475-2875-9-216
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发表时间：
2010-07-23
期刊：
影响因子：
3
通讯作者：
Lusingu JP
中科院分区：
文献类型：
--
作者：
Mmbando BP;Vestergaard LS;Kitua AY;Lemnge MM;Theander TG;Lusingu JP
由于疟疾负担随时间波动，疟疾干预措施的规划和评估十分复杂。最近，据报告，非洲一些地区的疟疾负担有所下降。然而，基于社区的纵向数据很少，对明显下降的原因也不甚了解。2003年至2008年，在坦桑尼亚东北部的两个村庄，即一个低地村庄和一个高地村庄，监测了疟疾的流行率和发病率。经过培训的乡村卫生工作者用坦桑尼亚一线抗疟疾药物治疗疑似疟疾患者，并收集血液涂片，随后进行检查。通过跨部门调查监测了疟疾寄生虫病的流行情况。低地村庄的疟疾寄生虫病流行率从2003年的78.4%下降到2008年的13.0%，而同期高地村庄的寄生虫病流行率从24.7%下降到3.1%。同样，这两个村庄的发热性疟疾发病率在同一时期下降了近85%，低地村庄患贫血症的幼儿人数明显减少。在过去几年中，研究村庄的疟疾发病率显著下降。这一下降可能是多种因素综合作用的结果，其中包括受过训练的乡村助理人员提供的疟疾治疗服务有所改善、杀虫剂浸渍蚊帐的供应有所增加，以及病媒密度有所降低。如果疟疾发病率持续下降，将对坦桑尼亚这一地区的疾病负担产生显著影响。
The planning and assessment of malaria interventions is complicated due to fluctuations in the burden of malaria over time. Recently, it has been reported that the burden of malaria in some parts of Africa has declined. However, community-based longitudinal data are sparse and the reasons for the apparent decline are not well understood. Malaria prevalence and morbidity have been monitored in two villages in north-eastern Tanzania; a lowland village and a highland village from 2003 to 2008. Trained village health workers treated presumptive malaria with the Tanzanian first-line anti-malarial drug and collected blood smears that were examined later. The prevalence of malaria parasitaemia across years was monitored through cross-sectional surveys. The prevalence of malaria parasitaemia in the lowland village decreased from 78.4% in 2003 to 13.0% in 2008, whereas in the highland village, the prevalence of parasitaemia dropped from 24.7% to 3.1% in the same period. Similarly, the incidence of febrile malaria episodes in the two villages dropped by almost 85% during the same period and there was a marked reduction in the number of young children who suffered from anaemia in the lowland village. There has been a marked decline in malaria in the study villages during the past few years. This decline is likely to be due to a combination of factors that include improved access to malaria treatment provided by the trained village helpers, protection from mosquitoes by increased availability of insecticide-impregnated bed nets and a reduced vector density. If this decline in malaria morbidity is sustained, it will have a marked effect on the disease burden in this part of Tanzania.
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影响因子：
--
作者：
Biai, Sidu;Rodrigues, Amabelia;Aaby, Peter
通讯作者：
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影响因子：
2.4
作者：
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影响因子：
3.3
作者：
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通讯作者：
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影响因子：
3
作者：
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通讯作者：
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影响因子：
168.9
作者：
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通讯作者：
Cohen, J