Cultivated oral mucosal epithelial transplantation for persistent epithelial defect in severe ocular surface diseases with acute inflammatory activity.
Cultivated oral mucosal epithelial transplantation for persistent epithelial defect in severe ocular surface diseases with acute inflammatory activity.
复制标题
DOI：
10.1111/aos.12397
复制
发表时间：
2014-09
影响因子：
3.4
通讯作者：
Kinoshita S
中科院分区：
文献类型：
--
作者：
Sotozono C;Inatomi T;Nakamura T;Koizumi N;Yokoi N;Ueta M;Matsuyama K;Kaneda H;Fukushima M;Kinoshita S
评估培养性口腔粘膜上皮移植（COMET）治疗持续性上皮缺损（PED）的临床疗效。 2002年至2008年，我们在日本京都府立医科大学使用COMET治疗了9名PED患者的10只眼睛（Stevens-Johnson综合征：3只眼；热/化学损伤：5只眼；眼部瘢痕性类天疱疮：2只眼）。术前，7只眼的角膜表面50%以上存在PED。所有 10 只眼睛的 PED 周围都有严重的眼表炎症和纤维血管组织。术后 24 周时，除 1 例患者无法返回医院外，所有病例的 PED 均有所改善（95% CI，55.5–99.7；Wilcoxon 符号秩检验，p = 0.0078）。术前对数最小分辨率中位数为1.85（范围0.15-2.70），术后第4、12和24周分别为1.85、1.85和1.52。术前眼表总分级平均评分为 7.0（范围 4-17）。术后4周和12周时，眼表总分级评分显着改善（p = 0.0020，p = 0.0078），术后24周时为3.0（范围2-12，p = 0.0234）。在随访期间（中位 23.3 个月，范围 5.6-39.7 个月），任何眼睛均未观察到 PED 复发，并且获得了长期眼表稳定性。 COMET使患有严重眼表疾病的患者能够实现PED的完全上皮化和眼表的稳定，从而防止晚期疤痕形成和视力丧失。
To assess the clinical efficacy of cultivated oral mucosal epithelial transplantation (COMET) for the treatment of persistent epithelial defect (PED). We treated 10 eyes of nine patients with PED (Stevens–Johnson syndrome: three eyes; thermal/chemical injury: five eyes; ocular cicatricial pemphigoid: two eyes) with COMET at Kyoto Prefectural University of Medicine, Kyoto, Japan from 2002 to 2008. Preoperatively, PED existed on over more than 50% of the corneal surface in seven eyes. Severe ocular surface inflammation with fibrovascular tissue surrounded the PED in all 10 eyes. At 24-weeks postoperative, PED had improved in all cases except 1 in which the patient was unable to return to the hospital (95% CI, 55.5–99.7; Wilcoxon signed-rank test, p = 0.0078). The preoperative median of logarithmic minimum angle of resolution was 1.85 (range 0.15–2.70), and 1.85, 1.85, and 1.52 at the 4th, 12th, and 24th postoperative week, respectively. The mean total preoperative ocular surface grading score was 7.0 (range 4–17). At 4 and 12 weeks postoperative, the total ocular surface grading score had improved significantly (p = 0.0020, p = 0.0078), and at 24 weeks postoperative, it was 3.0 (range 2–12, p = 0.0234). During the follow-up period (median 23.3 months, range 5.6–39.7 months), no recurrence of PED was observed in any eye, and long-term ocular surface stability was obtained. COMET enabled complete epithelialization of PED and stabilization of the ocular surface in patients with severe ocular surface disease, thus preventing end-stage cicatrization and vision loss at a later stage.
登录
查看更多内容
影响因子：
4.1
作者：
Nakamura, T;Inatomi, T;Kinoshita, S
通讯作者：
Kinoshita, S
影响因子：
13.7
作者：
Sotozono, Chie;Ang, Leonard P. K.;Kinoshita, Shigeru
通讯作者：
Kinoshita, Shigeru
影响因子：
3.9
作者：
Rahman, I.;Said, D. G.;Dua, H. S.
通讯作者：
Dua, H. S.
影响因子：
13.7
作者：
Gomes, JAP;dos Santos, MS;de Sousa, LB
通讯作者：
de Sousa, LB
影响因子：
13.7
作者：
Meller, D;Pires, RTF;Tseng, SCG
通讯作者：
Tseng, SCG