Stress-induced structural plasticity of medial amygdala stellate neurons and rapid prevention by a candidate antidepressant.
Stress-induced structural plasticity of medial amygdala stellate neurons and rapid prevention by a candidate antidepressant.
复制标题
DOI：
10.1038/mp.2016.68
复制
发表时间：
2017-02
影响因子：
11
通讯作者：
Nasca, C.
中科院分区：
文献类型：
--
作者：
Lau, T.;Bigio, B.;Zelli, D.;McEwen, B. S.;Nasca, C.
成年人的大脑能够通过结构可塑性来适应内部和外部的压力，如果不能保持正常的结构和功能，可能会导致抑郁症和焦虑症。虽然海马体为理解压力对大脑的影响提供了途径，但人们对杏仁核知之甚少，杏仁核是大脑中涉及恐惧和焦虑神经回路的关键区域。在更容易受到压力源影响的小鼠中，我们证明了杏仁核内侧和基底外侧区域在长时间21天的慢性约束应激（CRS）下的结构可塑性。在CRS结束前3天，在饮用水中使用公认的速效抗抑郁药乙酰左旋肉碱（LAC）治疗与这些变化方向相反。在行为上，在CRS的最后一部分，LAC治疗增强了韧性，与CRS的作用相反，在强迫游泳测试中，社会互动增加，被动行为减少。此外，用LAC治疗的CRS小鼠显示出CRS诱导的内侧杏仁核（MeA）星状神经元结构重塑的弹性。在杏仁核基底外侧（BLA）， LAC没有减少，但略有增强，crs增加了锥体神经元相交的长度和数量。MeA双极神经元、BLA星状神经元和外侧杏仁核（LA）星状神经元未见结构改变。我们的研究结果确定了MeA星状神经元是应激反应和LAC作用的重要组成部分，并表明LAC可以促进MeA的结构可塑性。这可能是一种有用的模型，用于增加风险人群对压力源的适应能力。
The adult brain is capable of adapting to internal and external stressors by undergoing structural plasticity, and failure to be resilient and preserve normal structure and function is likely to contribute to depression and anxiety disorders. While the hippocampus has provided the gateway for understanding stress effects on the brain, less is known about the amygdala, a key brain area involved in the neural circuitry of fear and anxiety. Here, in mice more vulnerable to stressors, we demonstrate structural plasticity within the medial and basolateral regions of the amygdala in response to prolonged 21day chronic restraint stress (CRS). Three days before the end of CRS, treatment with the putative, rapidly acting antidepressant, acetyl-L-carnitine (LAC) in the drinking water opposed the direction of these changes. Behaviorally, the LAC treatment during the last part of CRS enhanced resilience, opposing the effects of CRS, as shown by an increased social interaction and reduced passive behavior in a forced swim test. Furthermore, CRS mice treated with LAC show resilience of the CRS-induced structural remodeling of medial amygdala (MeA) stellate neurons. Within the basolateral (BLA) amygdala, LAC did not reduce, but slightly enhanced, the CRS-increased length and number of intersections of pyramidal neurons. No structural changes were observed in MeA bipolar neurons, BLA stellate neurons, or in lateral amygdala (LA) stellate neurons. Our findings identify MeA stellate neurons as an important component in the responses to stress and LAC action and show that LAC can promote structural plasticity of the MeA. This may be useful as a model for increasing resilience to stressors in at risk populations.
登录
查看更多内容
影响因子：
11
作者：
Nasca, C.;Bigio, B.;Zelli, D.;Nicoletti, F.;McEwen, B. S.
通讯作者：
McEwen, B. S.
影响因子：
3.3
作者：
MAGARINOS, AM;MCEWEN, BS
通讯作者：
MCEWEN, BS
DOI：
10.1073/pnas.1216100110
发表时间：
2013-03-19
影响因子：
11.1
作者：
Nasca, Carla;Xenos, Dionysios;Nicoletti, Ferdinando
通讯作者：
Nicoletti, Ferdinando
DOI：
10.1073/pnas.1516016112
发表时间：
2015-12-01
影响因子：
11.1
作者：
Nasca, Carla;Zelli, Danielle;McEwen, Bruce S.
通讯作者：
McEwen, Bruce S.
影响因子：
5
作者：
McEwen, Bruce S;Gray, Jason;Nasca, Carla
通讯作者：
Nasca, Carla