Correlation between quantitative analysis of wall shear stress and intima-media thickness in atherosclerosis development in carotid arteries.
Correlation between quantitative analysis of wall shear stress and intima-media thickness in atherosclerosis development in carotid arteries.
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DOI：
10.1186/s12938-017-0425-9
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发表时间：
2017-12-06
影响因子：
3.9
通讯作者：
Ghista D
中科院分区：
文献类型：
--
作者：
Zhang B;Gu J;Qian M;Niu L;Zhou H;Ghista D
本文通过测量实验兔每周饲喂高脂饲料导致动脉粥样硬化的颈动脉壁剪切应力（WSS）和内膜-中膜厚度（IMT），定量分析血流剪切应力。本研究建立高脂家兔动脉粥样硬化模型，每周测量实验组和对照组家兔颈总动脉WSS。采用WSS定量法进行详细分析。我们发现，从第1周开始，实验组与对照组的颈动脉WSS差异有统计学意义（P<0.01），而从第5周开始，实验组的颈动脉IMT与对照组的差异有统计学意义（P<0.05）。接下来，我们已经证明，随着血脂的升高，兔颈动脉剪应力减小，兔颈动脉IMT升高。剪切应力的减小出现在IMT生长开始之前。此外，我们的受试者操作特征（ROC）曲线分析显示，当剪应力均值为1.198达因/cm2时，兔颈总动脉粥样硬化脂肪条纹的敏感性为89.8%，特异性为81.3%。ROC曲线下面积为0.9283。以上数据表明，WSS降至1.198 dyne/cm2时，可作为兔颈总动脉进入纤维斑块期的指标。综上所述，我们的研究能够发现并证实动脉WSS的降低可以更早地预测动脉粥样硬化的发生，为临床积极干预提供帮助。
This paper presents quantitative analysis of blood flow shear stress by measuring the carotid arterial wall shear stress (WSS) and the intima-media thickness (IMT) of experimental rabbits fed with high-fat feedstuff on a weekly basis in order to cause atherosclerosis. This study is based on establishing an atherosclerosis model of high-fat rabbits, and measuring the rabbits’ common carotid arterial WSS of the experimental group and control group on a weekly basis. Detailed analysis was performed by using WSS quantification. We have demonstrated small significant difference of rabbit carotid artery WSS between the experimental group and the control group (P<0.01) from the 1st week onwards, while the IMT of experimental group had larger differences from 5th week compared with the control group (P<0.05). Next, we have shown that with increasing blood lipids, the rabbit carotid artery shear stress decreases and the rabbit carotid artery IMT goes up. The decrease of shear stress appears before the start of IMT growth. Furthermore, our receiver operator characteristic (ROC) curve analysis showed that when the mean value of shear stress is 1.198 dyne/cm2, the rabbit common carotid atherosclerosis fatty streaks sensitivity is 89.8%, and the specificity is 81.3%. The area under the ROC curve is 0.9283. All these data goes to show that WSS decreasing to 1.198 dyne/cm2 can be used as an indicator that rabbit common carotid artery comes into the period of fibrous plaques. In conclusion, our study is able to find and confirm that the decrease of the arterial WSS can predict the occurrence of atherosclerosis earlier, and offer help for positive clinical intervention.
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