Resident mesenchymal cells and fibrosis.
Resident mesenchymal cells and fibrosis.
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DOI：
10.1016/j.bbadis.2012.11.015
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发表时间：
2013-07
影响因子：
6.2
通讯作者：
Duffield, Jeremy S.
中科院分区：
文献类型：
--
作者：
Hutchison, Nicol;Fligny, Cecile;Duffield, Jeremy S.
关键词：
纤维化是一个主要的临床问题，与发达国家所有自然死亡的45%相关。它可以影响所有器官，并且越来越多的证据表明，纤维化不仅仅是损伤的旁观者产物，而是直接导致器官功能丧失的中心病理学问题。在大多数临床病例中，纤维化与白细胞的募集密切相关，即使在没有感染的情况下也是如此。虽然慢性感染是纤维发生的重要原因，但在大多数情况下，纤维化疾病发生在无菌损伤的背景下，如微血管疾病、毒性上皮损伤或糖尿病。纤维化是我们器官中大量的、以前很少被认识到的间充质细胞群激活的直接结果，所述间充质细胞群要么包裹在毛细血管周围并被称为“周细胞”，要么嵌入细胞结构之间的间隙中并被称为常驻“成纤维细胞”。最近在几个器官中的命运映射和补充研究表明，这些细胞是疤痕形成肌成纤维细胞的前体，这些细胞在我们的器官中出现对损伤的反应。在这里，我们将回顾文献支持这些细胞在纤维化中的核心作用，并强调一些关键的细胞与细胞的相互作用，是必要的纤维化过程的启动和持续。这篇文章是特刊的一部分，题为：纤维化：基础研究对人类疾病的翻译。
Fibrosis is a major clinical problem associated with as many as 45% of all natural deaths in developed nations. It can affect all organs and accumulating evidence indicates that fibrogenesis is not merely a bystander product of injury, but is a central pathological problem directly contributing to loss of organ function. In the majority of clinical cases, fibrogenesis is strongly associated with the recruitment of leukocytes, even in the absence of infection. Although chronic infections are a significant cause of fibrogenesis, in most cases fibrotic disease occurs in the context of sterile injury, such as microvascular disease, toxic epithelial injury or diabetes mellitus. Fibrogenesis is a direct consequence of the activation of extensive, and previously poorly appreciated, populations of mesenchymal cells in our organs which are either wrapped around capillaries and known as ‘pericytes’, or embedded in interstitial spaces between cell structures and known as resident ‘fibroblasts’. Recent fate-mapping and complementary studies in several organs indicate that these cells are the precursors of the scar-forming myofibroblasts that appear in our organs in response to injury. Here we will review the literature supporting a central role for these cells in fibrogenesis, and highlight some of the critical cell to cell interactions that are necessary for the initiation and continuation of the fibrogenic process. This article is part of a Special Issue entitled: Fibrosis: Translation of basic research to human disease.
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DOI：
10.1152/ajplung.00417.2002
发表时间：
2003-08-01
影响因子：
4.9
作者：
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DOI：
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发表时间：
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影响因子：
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