Clinical surrogate markers for predicting metabolic syndrome in middle-aged and elderly Chinese.
Clinical surrogate markers for predicting metabolic syndrome in middle-aged and elderly Chinese.
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DOI：
10.1111/jdi.12708
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发表时间：
2018-03
影响因子：
3.2
通讯作者：
Xie P
中科院分区：
文献类型：
--
作者：
Li R;Li Q;Cui M;Yin Z;Li L;Zhong T;Huo Y;Xie P
本研究评价了脂质蓄积乘积（Lipid accumulation product，CYP）、内脏肥胖指数（visceral adiposity index，VAI）和甘油三酯与葡萄糖乘积（TG/glucose product，TyG）这三种新指标在中国中老年人不同标准代谢综合征（metabolic syndrome，MetS）诊断中的能力。2012年6月至2013年1月期间，大坪医院入组了992例连续患者（年龄≥40岁）。MetS的标准是基于国际糖尿病联盟和修改后的国家胆固醇教育计划的成人治疗面板III。VAI、VAI和TyG是根据已发表的数学模型计算的。代谢综合征的患病率为42.8%。受试者工作特征曲线发现，在两个标准中，MetS与VAI、TyG呈正相关。对于修改后的国家胆固醇教育计划成人治疗组III和国际糖尿病联合会标准，VAI、VAI和TyG的最佳临界值分别为2.015、31.465和8.706，以及2.035、37.99和8.697。在调整潜在混杂因素后，根据最佳临界值，所有标准中VAI、VAI和TyG均与MetS显著相关。对于MetS，在不同亚组（年龄和性别）中观察到可靠的预测值。根据国际糖尿病联合会的定义，MetS的曲线下面积最大（曲线下面积为0.887，95%置信区间为0.852-0.922）。 AP、VAI和TyG是鉴别中国中老年MetS的可靠替代标志物。与VAI和TyG相比，在目前的研究中，EMT可能是一个更好的预测MetS的参数。
The present study evaluated the ability of lipid accumulation product (LAP), visceral adiposity index (VAI), and the product of triglycerides and glucose (TyG), three novel markers, in identifying metabolic syndrome (MetS) with different criteria in middle‐aged and elderly Chinese. During June 2012 to January 2013, 992 consecutive patients (age ≥40 years) were enrolled at Daping Hospital. The criteria of MetS were based on the International Diabetes Federation and the modified National Cholesterol Education Program's Adult Treatment Panel III. VAI, LAP and TyG were computed based on a published mathematical model. The prevalence of MetS was 42.8%. The receiver operating characteristic curve found LAP, VAI and TyG were positively related to MetS in both criteria. The optimal cut‐offs of VAI, LAP and TyG for the modified National Cholesterol Education Program's Adult Treatment Panel III and International Diabetes Federation criteria were 2.015, 31.465 and 8.706, and 2.035, 37.99 and 8.697, respectively. After adjustment of potential confounding factors, VAI, LAP and TyG were significantly correlated with MetS in all criteria according to optimal cut‐offs. For MetS, reliable predictive value was observed in different subgroups (age and sex). LAP showed the greatest area under the curve in MetS with the International Diabetes Federation definition (area under the curve 0.887, 95% confidence interval 0.852–0.922). AP, VAI and TyG were reliable surrogate markers for identifying MetS in middle‐aged and elderly Chinese. LAP could be a better parameter than VAI and TyG for predicting MetS in the present study.
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影响因子：
1.9
作者：
Knowles KM;Paiva LL;Sanchez SE;Revilla L;Lopez T;Yasuda MB;Yanez ND;Gelaye B;Williams MA
通讯作者：
Williams MA
影响因子：
2.1
作者：
Kahn HS
通讯作者：
Kahn HS
影响因子：
5.8
作者：
Taverna, Mariano J.;Martinez-Larrad, Maria T.;Serrano-Rios, Manuel
通讯作者：
Serrano-Rios, Manuel
影响因子：
3.7
作者：
Lee SH;Kwon HS;Park YM;Ha HS;Jeong SH;Yang HK;Lee JH;Yim HW;Kang MI;Lee WC;Son HY;Yoon KH
通讯作者：
Yoon KH
影响因子：
120.7
作者：
Lakka, HM;Laaksonen, DE;Salonen, JT
通讯作者：
Salonen, JT