Autophagy paradox and ceramide.
Autophagy paradox and ceramide.
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DOI：
10.1016/j.bbalip.2013.09.005
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发表时间：
2014-05
期刊：
影响因子：
--
通讯作者：
Ogretmen B
中科院分区：
文献类型：
--
作者：
Jiang W;Ogretmen B
鞘脂分子充当生物活性脂质信使，并在各种细胞信号传导途径的调节中发挥作用。鞘脂在许多细胞功能中发挥重要作用，包括控制细胞炎症、增殖、死亡、迁移、衰老、肿瘤转移和/或自噬。鞘脂代谢失调也与许多人类癌症有关。巨自噬（此处称为自噬）“自噬”，其特征是通过隔离膜非选择性地隔离胞质物质，这对细胞可以是保护性的，也可以是致命性的。神经酰胺 (Cer) 是鞘脂代谢的中心分子，广泛参与自噬的控制。越来越多的证据表明，Cer 高度参与介导两种相反的自噬途径，调节细胞的生存或死亡，即自噬悖论。然而，调节自噬悖论的潜在机制仍不清楚。因此，本文重点综述近年来有关Cer调节自噬的研究，阐明Cer在控制自噬悖论中的作用和作用机制。
Sphingolipid molecules act as bioactive lipid messengers and exert their actions on the regulation of various cellular signaling pathways. Sphingolipids play essential roles in numerous cellular functions, including controlling cell inflammation, proliferation, death, migration, senescence, tumor metastasis and/or autophagy. Dysregulated sphingolipid metabolism has been also implicated in many human cancers. Macroatuophagy (referred to here as autophagy) “self-eating”, is characterized by nonselective sequestering of cytosolic materials by an isolation membrane, which can be either protective or lethal for cells. Ceramide (Cer), a central molecule of sphingolipid metabolism, has been extensively implicated in the control of autophagy. The increasing evidence suggests Cer is highly involved in mediating two opposing autophagic pathways, which regulate either cell survival or death, autophagy paradox. However, the underlying mechanism that regulates the autophagy paradox remains unclear. Therefore, this review focuses on recent studies with regard to the regulation of autophagy by Cer and elucidate the roles and mechanisms of action of Cer in controlling autophagy paradox.
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