Disease due to the Mycobacterium avium complex in patients with AIDS: epidemiology and clinical syndrome.
Disease due to the Mycobacterium avium complex in patients with AIDS: epidemiology and clinical syndrome.
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艾滋病患者中由鸟分枝杆菌复合体引起的疾病：流行病学和临床综合征。
DOI：
10.1093/clinids/18.supplement_3.s218
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Constance A. Benson
中科院分区：
文献类型：
--
作者：
Constance A. Benson
禽型分枝杆菌复合体(MAC)感染是美国艾滋病患者中最常见的细菌源机会性疾病。近年来，由MAC(DMAC)引起的播散性疾病的发病率急剧上升。随着CD4+淋巴细胞数量降至100/mm3，罹患DMAC的风险也随之增加。几项研究的初步分析表明，感染人类免疫缺陷病毒的性别、种族或民族以及个人危险因素不会影响DMAC的发病率，但既往卡氏肺孢子虫肺炎、严重贫血的发展或抗逆转录病毒治疗的中断可能会增加风险。呼吸道和胃肠道可能都是MAC的入口。殖民可能会增加DMAC的风险，但并不总是先于传播。患有艾滋病和DMAC的患者比那些患有艾滋病但没有DMAC的患者存活时间更短。虽然DMAC的治疗可以延长生存期，但没有任何良好控制的、前瞻性的、随机的临床试验记录了这一点。大多数患有艾滋病和DMAC的患者都患有播散性多器官疾病；最常见的症状包括发热、盗汗、体重减轻或消瘦、腹泻和腹痛。最常见的实验室异常是贫血和血清碱性磷酸酶水平升高。与MAC感染相关的局部性疾病综合征较少发生。
Infection due to the Mycobacterium avium complex (MAC) is the most common opportunistic disease of bacterial origin among patients with AIDS in the United States. The incidence of disseminated disease due to MAC (DMAC) has risen dramatically in recent years. The risk of developing DMAC increases as the CD4+ lymphocyte count declines to < 100/mm3. Preliminary analyses of several studies suggest that gender, racial or ethnic group, and individual risk factors for human immunodeficiency virus infection do not influence the incidence of DMAC but that prior Pneumocystis carinii pneumonia, the development of severe anemia, or the interruption of antiretroviral therapy may increase risk. Both the respiratory and the gastrointestinal tracts probably serve as portals of entry for MAC. Colonization may potentiate the risk of DMAC but does not always precede dissemination. Patients with AIDS and DMAC have a shorter duration of survival than do those with AIDS but without DMAC. While treatment for DMAC may extend survival, no well-controlled, prospective, randomized clinical trial has documented this point. Most patients with AIDS and DMAC have disseminated multiorgan disease; the most frequently described symptoms include fever, night sweats, weight loss or wasting, diarrhea, and abdominal pain. The most commonly identified laboratory abnormalities are anemia and elevated serum levels of alkaline phosphatase. Localized disease syndromes related to MAC infection occur less often.
环孢素治疗的大鼠静脉内和口服攻击后鸟分枝杆菌复合体进行性播散性感染。
DOI：
10.1093/infdis/164.5.922
发表时间：
1991
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Brown,ST;Edwards,FF;Bernard,EM;Niki,Y;Armstrong,D
通讯作者：
Armstrong,D
患有获得性细胞介导免疫缺陷的同性恋男性中传播的鸟胞内分枝杆菌感染：两例病例的组织学和免疫学研究。
影响因子：
3.5
作者：
Sohn,CC;Schroff,RW;Kliewer,KE;Lebel,DM;Fligiel,S
通讯作者：
Fligiel,S
人类免疫缺陷病毒感染患者的分枝杆菌病。
影响因子：
--
作者：
Modilevsky,T;Sattler,FR;Barnes,PF
通讯作者：
Barnes,PF