Type 1 diabetes onset in Lombardy region, Italy, during the COVID-19 pandemic: The double-wave occurrence.
Type 1 diabetes onset in Lombardy region, Italy, during the COVID-19 pandemic: The double-wave occurrence.
复制标题
DOI：
10.1016/j.eclinm.2021.101067
复制
发表时间：
2021-09
影响因子：
15.1
通讯作者：
Bonfanti R
中科院分区：
文献类型：
--
作者：
Mameli C;Scaramuzza A;Macedoni M;Marano G;Frontino G;Luconi E;Pelliccia C;Felappi B;Guerraggio LP;Spiri D;Macellaro P;Chiara Redaelli F;Cardani R;Zampolli M;Calcaterra V;Sordelli S;Calzi E;Cogliardi A;Brambilla I;Pistone C;Rigamonti A;Boracchi P;Biganzoli E;Zuccotti GV;Bonfanti R
自二零二零年二月以来，意大利伦巴第大区一直是COVID-19的震中。本研究分析了前两次大流行期间和前三年儿童1型糖尿病（T1 D）发病的流行病学。伦巴第大区的所有13家儿科糖尿病中心在2020年期间前瞻性评价了T1 D发作（0-17岁）儿童的图表。在计算出年发病率后，使用广义线性模型，对年龄和性别进行调整，将数据与前3年的数据进行比较。从2017年至2020年，每年调查每月T1 D新发病例和糖尿病酮症酸中毒（DKA）。数据来自儿科糖尿病中心的门诊病人图表和国家统计研究所的数据库。2020年T1 D的估计发病率比例为16/100·000，而2019年、2018年和2017年分别为14、11和12。当调整年龄和性别时，与2020年相比，2018年和2017年的发病率明显降低（校正后的发病比分别为0.73和0.77，95% CI分别为0.63 ~ 0.84和0.67 ~ 0.83; p = 0.002和p = 0.01），但2020年和2019年之间没有发现差异。与往年相比，第一波（3月至4月）T1 D诊断占全年诊断的百分比呈下降趋势（2020年为11.7%，2019年为17.7%，2018年为14.1%，2017年为14.4%）。在第二波（12月至12月）期间没有观察到任何差异（2020年为32.8%，2019年为33.8%，2018年为34%，2017年为30.7%）。第二波DKA占T1 D诊断总数的比例高于第一波（41.7%vs33.3%），而第一波重度DKA占DKA总数的比例高于第二波（60%vs37.1%）。该研究表明，在过去五年中，伦巴第大区儿童T1 D的发病率有所增加。流行波可能影响了发病时的临床表现。没有。
The Italian Lombardy region has been the epicenter of COVID-19 since February 2020. This study analyses the epidemiology of pediatric type 1 diabetes (T1D) onset during the first two pandemic waves and three previous years. All the 13 pediatric diabetes centers in Lombardy prospectively evaluated charts of children at T1D onset (0–17 years), during year 2020. After calculating the annual incidence, the data were compared with those of the 3 previous years, using generalized linear models, adjusted for age and sex. Monthly T1D new onsets and diabetic ketoacidosis (DKA) were investigated yearly from 2017 to 2020. Data were extracted from outpatients charts of the pediatric diabetes centers and from the database of the national institute of statistics. The estimated incidence proportion of T1D was 16/100·000 in 2020, compared to 14, 11 and 12 in 2019, 2018 and 2017, respectively. When adjusting for age and gender, the incidence was significantly lower in 2018 and 2017 compared to 2020 (adjusted incidence ratio: 0.73 and 0.77 respectively, with 95% CI: 0.63 to 0.84, and 0.67 to 0.83; p = 0·002 and p = 0·01), but no difference was found between the years 2020 and 2019. A reduction trend in the percentage of T1D diagnosis during the first wave (March-April) over the total year diagnoses was observed compared to previous years (11·7% in 2020, 17·7% in 2019, 14·1% in 2018 and 14·4% 2017). No difference was observed during the second wave (October-December) (32·8% in 2020, 33·8% in 2019, 34% in 2018, 30·7% in 2017). The proportion of DKA over the total T1D diagnoses during the second wave had higher trend than the first one (41·7% vs 33·3%), while severe DKA over the total DKA appeared higher during the first wave (60% vs 37·1%). The study suggests an increase in the incidence of pediatric T1D in Lombardy throughout the past five years. Pandemic waves may have affected the clinical presentation at onset. None.
登录
查看更多内容
影响因子：
3.4
作者：
Mayer-Davis, Elizabeth J.;Kahkoska, Anna R.;Craig, Maria E.
通讯作者：
Craig, Maria E.
影响因子：
8.2
作者：
Patterson, Christopher C.;Harjutsalo, Valma;Green, Anders
通讯作者：
Green, Anders
影响因子：
9.3
作者：
McCabe R;Schmit N;Christen P;D'Aeth JC;Løchen A;Rizmie D;Nayagam S;Miraldo M;Aylin P;Bottle A;Perez-Guzman PN;Ghani AC;Ferguson NM;White PJ;Hauck K
通讯作者：
Hauck K
影响因子：
3.8
作者：
Iafusco, D.;Massa, O.;Barbetti, F.
通讯作者：
Barbetti, F.
影响因子：
3.4
作者：
Fox, Danya A.;Islam, Nazrul;Amed, Shazhan
通讯作者：
Amed, Shazhan