The analgesic effect of different interactive modes of virtual reality: A prospective functional near-infrared spectroscopy (fNIRS) study.
The analgesic effect of different interactive modes of virtual reality: A prospective functional near-infrared spectroscopy (fNIRS) study.
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DOI：
10.3389/fnins.2022.1033155
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发表时间：
2022
影响因子：
4.3
通讯作者：
Zhao S
中科院分区：
文献类型：
--
作者：
Deng X;Jian C;Yang Q;Jiang N;Huang Z;Zhao S
虚拟现实已经证明了它的止痛效果。然而，其缓解疼痛的最佳交互模式尚不清楚，很少有人进行客观测量来探索其神经机制。本研究主要通过功能近红外光谱(FNIRS)研究不同VR互动模式的镇痛效果，并通过自评问卷探讨其与主观报告的VR体验的相关性。健康志愿者15例，年龄21.93±0.59岁，女性11例，男性4例。在一致伤害性电刺激(电强度：23.67±5.69 mA)下，先后促成了主动模式、运动想象(MI)模式和被动模式三轮交互模式。采用重复测量方差分析(ANOVA)检查其疼痛缓解状态和皮质激活情况，并在Bonferroni矫正后进行后继分析。采用Spearman相关检验，探讨VR问卷(VRQ)项目与皮层激活的关系。与被动模式相比，主动模式(−1.4(95%CI，−2.23to−0.57)，p=0.001)和MI模式(−0.667(95%CI，−1.165至−0.168，p=0.012)的止痛效果更好，两种模式之间的止痛效果没有显著差异(−0.733(95%CI，−1.631至165)，p=0.131)。与负责运动和认知功能的不同激活的皮质感兴趣区(ROI)相关，包括左侧初级运动皮质(LM1)、左侧背侧前额叶皮质(LDLPFC)、左侧初级躯体感觉皮质(LS1)、左侧枕叶视觉皮质(LOL)和左侧前运动皮质(LPMC)。另一方面，VRQ项目与不同皮层ROI(r=−0.629~0.722，p<；0.05)及其对应通道(r=−0.599~0.788，p<；0.05)之间存在显著的相关性。我们的研究结果表明，VR可以被认为是一种通过调节皮质疼痛处理来缓解疼痛的有效的非侵入性方法。兴奋和整合负责运动和认知功能的皮质感兴趣区可以获得更好的止痛效果。交互模式可以很容易地定制以符合患者的特征，尽管当可以获得同等的止痛效果时，皮质激活状态不同。
Virtual reality has demonstrated its analgesic effectiveness. However, its optimal interactive mode for pain relief is yet unclear, with rare objective measurements that were performed to explore its neural mechanism. This study primarily aimed at investigating the analgesic effect of different VR interactive modes via functional near-infrared spectroscopy (fNIRS) and exploring its correlations with the subjectively reported VR experience through a self-rating questionnaire. Fifteen healthy volunteers (Age: 21.93 ± 0.59 years, 11 female, 4 male) were enrolled in this prospective study. Three rounds of interactive mode, including active mode, motor imagery (MI) mode, and passive mode, were successively facilitated under consistent noxious electrical stimuli (electrical intensity: 23.67 ± 5.69 mA). Repeated-measures of analysis of variance (ANOVA) was performed to examine its pain relief status and cortical activation, with post hoc analysis after Bonferroni correction performed. Spearman's correlation test was conducted to explore the relationship between VR questionnaire (VRQ) items and cortical activation. A larger analgesic effect on the active (−1.4(95%CI, −2.23 to −0.57), p = 0.001) and MI modes (−0.667(95%CI, −1.165 to −0.168), p = 0.012) was observed compared to the passive mode in the self–rating pain score, with no significant difference reported between the two modes (−0.733(95%CI, −1.631 to.165), p = 0.131), associated with diverse activated cortical region of interest (ROI) in charge of motor and cognitive functions, including the left primary motor cortex (LM1), left dorsal–lateral prefrontal cortex (LDLPFC), left primary somatosensory cortex (LS1), left visual cortex at occipital lobe (LOL), and left premotor cortex (LPMC). On the other hand, significant correlations were found between VRQ items and different cortical ROIs (r = −0.629 to 0.722, p < 0.05) as well as its corresponding channels (r = −0.599 to 0.788, p < 0.05). Our findings suggest that VR can be considered as an effective non-invasive approach for pain relief by modulating cortical pain processing. A better analgesic effect can be obtained by exciting and integrating cortical ROIs in charge of motor and cognitive functions. The interactive mode can be easily tailored to be in line with the client's characteristics, in spite of the diverse cortical activation status when an equivalent analgesic effect can be obtained.
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DOI：
10.1016/j.berh.2015.04.022
发表时间：
2015-02
期刊：
Best practice & research. Clinical rheumatology
影响因子：
--
作者：
Ambrose KR;Golightly YM
通讯作者：
Golightly YM
影响因子：
5.3
作者：
Apkarian, AV;Sosa, Y;Gitelman, DR
通讯作者：
Gitelman, DR
DOI：
10.3233/978-1-60750-766-6-69
发表时间：
2011-01-01
期刊：
ANNUAL REVIEW OF CYBERTHERAPY AND TELEMEDICINE 2011: ADVANCED TECHNOLOGIES IN BEHAVIORAL, SOCIAL AND NEUROSCIENCES
影响因子：
--
作者：
Gutierrez-Maldonado, Jose;Gutierrez-Martinez, Olga;Cabas-Hoyos, Katia
通讯作者：
Cabas-Hoyos, Katia
影响因子：
2.9
作者：
Hoffman, Hunter G.;Patterson, David R.;Sharar, Sam R.
通讯作者：
Sharar, Sam R.
影响因子：
22.4
作者：
MCCAUL, KD;MALOTT, JM
通讯作者：
MALOTT, JM