Anatomical and functional deficits in patients with amnestic mild cognitive impairment.
Anatomical and functional deficits in patients with amnestic mild cognitive impairment.
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遗忘型轻度认知障碍患者的解剖和功能缺陷
DOI：
10.1371/journal.pone.0028664
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Jia J
中科院分区：
文献类型：
--
作者：
Han Y;Lui S;Kuang W;Lang Q;Zou L;Jia J
背景遗忘型轻度认知功能障碍（MCI）患者的解剖和功能缺陷已被研究。然而，目前尚不清楚解剖缺陷是否以及如何与功能改变相关。本研究旨在描述MCI患者解剖和功能缺陷之间的关系。方法对17例遗忘型MCI患者和18例健康老年人进行MRI T1 WI和梯度回波二维成像。采用临床痴呆评定量表、简易精神状态检查量表（MMSE）、画钟测验、听觉言语学习测验和日常生活活动能力量表对MCI患者的临床严重程度进行评估。用DARTEL的VBM来表征MCI的灰质缺陷。用低频波动幅度（ALFF）评价MCI患者的局部功能改变，并计算慢4（0.027-0.073 Hz）和慢5（0.01 -0.027 Hz）的ALFF分数（fALFF）。结果遗忘型MCI患者大脑灰质体积（GMV）明显减少，主要分布在双侧前额叶、左侧颞叶和后扣带回。左侧额下回GMV与MMSE评分呈显著正相关。MCI组ALFF/fALFF降低主要在前额叶、左顶叶和右侧梭状回，而ALFF/fALFF升高主要在边缘系统和中脑。MCI患者慢5带fALFF的变化大于慢4带。形态测量和功能结果之间没有显着的相关性。结论MCI患者广泛性脑体积缩小同时伴有局部脑功能的降低和增强，而解剖和功能改变是相互独立的。因此，结构和功能MRI方法的结合将提供互补的信息，并共同推进我们对MCI症状的病理生理学的理解。
Background Anatomical and functional deficits have been studied in patients with amnestic mild cognitive impairment (MCI). However, it is unclear whether and how the anatomical deficits are related to the functional alterations. Present study aims to characterize the association between anatomical and functional deficits in MCI patients. Methods Seventeen amnestic MCI patients and 18 healthy aging controls were scanned using a T1 Weighted MPRAGE sequence and a gradient-echo echo-planar imaging sequence. Clinical severity of MCI patients was evaluated by using Clinical Dementia Rating, Mini Mental State Examination (MMSE), Clock Drawing Test, Auditory Verbal Learning Test and Activities of Daily Living. VBM with DARTEL was used to characterize the gray matter deficits in MCI. Regional amplitude of low-frequency (0.01–0.08 Hz) fluctuations (ALFF) was used to evaluate regional functional alteration in MCI and fractional ALFF(fALFF) in slow 4 (0.027–0.073 Hz) and slow 5 (0.01–0.027 Hz) were also calculated. Results Significantly decreased gray matter volume (GMV) was observed in amnestic MCI group mainly in bilateral prefrontal, left temporal and posterior cingulate cortex. Significant positive correlation was observed between the GMV in left inferior frontal gyrus and MMSE scores. Interestingly, decreased ALFF/fALFF was revealed in MCI group compared to controls mainly in prefrontal, left parietal regions and right fusiform gyrus, while the increased ALFF/fALFF was found in limbic and midbrain. Furthermore, the changes of fALFF in MCI in the slow-5 band were greater than those in the slow-4. No significant correlation was found between the morphometric and functional results. Conclusions Findings from the study document that wide spread brain volume reduction accompanied with decreased and increased regional function in MCI, while the anatomical and functional changes were independently. Therefore, the combination of structural and functional MRI methods would provide complementary information and together advance our understanding of the pathophysiology underlying the symptoms of MCI.
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5.7
作者：
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影响因子：
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通讯作者：
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