Thymic stromal lymphopoietin, skin barrier dysfunction, and the atopic march.
Thymic stromal lymphopoietin, skin barrier dysfunction, and the atopic march.
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DOI：
10.1016/j.anai.2021.06.004
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Ziegler SF
中科院分区：
文献类型：
--
作者：
Ziegler SF
特应性皮炎通常先于其他特应性疾病的发展，特应性进行史描述了这些疾病的自然史中的这种时间关系。尽管这种关系背后的病理生理机制尚不清楚，但流行病学和遗传学数据表明，皮肤可能是对过敏原致敏的重要途径。最近发表的关于皮肤屏障缺陷和上皮动物模型表达之间关系的文章已经开始阐明皮肤屏障缺陷如何导致全身过敏原致敏。新出现的数据表明，上皮细胞来源的细胞因子，如胸腺基质淋巴生成素（TSLP），推动了特应性皮炎向哮喘和食物过敏的进展。皮肤屏障缺陷可导致上皮细胞源性细胞因子的诱导，进而导致过敏性炎症和特应性病程的启动和维持。针对2型细胞因子的新型生物药物的开发为特应性皮炎的治疗提供了新的干预手段。
Atopic dermatitis often precedes the development of other atopic diseases, and the atopic march describes this temporal relationship in the natural history of these diseases. Although the pathophysiological mechanisms that underlie this relationship are poorly understood, epidemiological and genetic data have suggested that the skin might be an important route of sensitization to allergens Review of recent studies on the role of skin barrier defects in systemic allergen sensitization. Recent publications on the relationship between skin barrier defects and expression of epithelial Animal models have begun to elucidate how skin barrier defects can lead to systemic allergen sensitization. Emerging data now suggest that epithelial cell-derived cytokines such as thymic stromal lymphopoietin (TSLP) drive the progression from atopic dermatitis to asthma and food allergy. Skin barrier defects can lead to induction of epithelial cell-derived cytokines, which in turn leads to the initiation and maintenance of allergic inflammation and the atopic march. Development of new biologic drug targeting type 2 cytokines provide novel therapeutic interventions for atopic dermatitis.
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DOI：
10.1084/jem.20082242
发表时间：
2009-05-11
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Briot A;Deraison C;Lacroix M;Bonnart C;Robin A;Besson C;Dubus P;Hovnanian A
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DOI：
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发表时间：
2011-03
期刊：
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影响因子：
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作者：
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通讯作者：
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影响因子：
15.9
作者：
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DOI：
10.1186/s13223-016-0158-5
发表时间：
2016
期刊：
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
影响因子：
--
作者：
Bin L;Leung DY
通讯作者：
Leung DY
影响因子：
2.6
作者：
Hahn, EL;Bacharier, LB
通讯作者：
Bacharier, LB