NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection
NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection
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NCoR1 通过抑制 Bim 表达来抑制胸腺负选择，从而避免胸腺细胞经历正选择
DOI：
10.1038/s41467-017-00931-8
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发表时间：
2017-10
影响因子：
16.6
通讯作者：
Leng Qibin
中科院分区：
文献类型：
--
作者：
Jianrong Wang;Nanhai He;Na Zhang;Dexian Quan;Shuo Zhang;Shuo Zhang;Ruth T. Yu;nnette R. Atkins;Ruihong Zhu;Chunhui Yang;Ying Cui;Christopher Liddle;Michael Downes;Hui Xiao;Ye Zheng;Johan Auwerx;Ronald M. Evans;Leng Qibin
胸腺细胞必须通过阳性和阴性选择成为成熟的T细胞。阴性选择清除其T细胞受体（TCR）对自肽MHC复合物（自PMHC）的胸腺细胞，以避免自身免疫性疾病，而POSI
Thymocytes must pass both positive and negative selections to become mature T cells. Negative selection purges thymocytes whose T-cell receptors (TCR) exhibit high affinity to self-peptide MHC complexes (self pMHC) to avoid autoimmune diseases, while positive selection ensures the survival and maturation of thymocytes whose TCRs display intermediate affinity to self pMHCs for effective immunity, but whether transcriptional regulation helps conserve positively selected thymocytes from being purged by negative selection remains unclear. Here we show that the specific deletion of nuclear receptor co-repressor 1 (NCoR1) in T cells causes excessive negative selection to reduce mature thymocyte numbers. Mechanistically, NCoR1 protects positively selected thymocytes from negative selection by suppressing Bim expression. Our study demonstrates a critical function of NCoR1 in coordinated positive and negative selections in the thymus.
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影响因子：
5.3
作者：
K. Stengel;Yue Zhao;Nicholas J. Klus;Jonathan F Kaiser;Laura E. Gordy;S. Joyce;S. Hiebert;Alyssa R Summers
通讯作者：
K. Stengel;Yue Zhao;Nicholas J. Klus;Jonathan F Kaiser;Laura E. Gordy;S. Joyce;S. Hiebert;Alyssa R Summers
影响因子：
5.4
作者：
G. Heine;K. Anton;B. Henz;M. Worm
通讯作者：
G. Heine;K. Anton;B. Henz;M. Worm
DOI：
10.1073/pnas.1522821113
发表时间：
2016-02-02
影响因子：
11.1
作者：
Hua, Guoqiang;Paulen, Laetitia;Chambon, Pierre
通讯作者：
Chambon, Pierre
影响因子：
32.4
作者：
Neilson, JR;Winslow, MM;Crabtree, GR
通讯作者：
Crabtree, GR
影响因子：
64.5
作者：
Jepsen, K;Hermanson, O;Rosenfeld, MG
通讯作者：
Rosenfeld, MG