HIV infection among men who have sex with men in Kampala, Uganda--a respondent driven sampling survey.
HIV infection among men who have sex with men in Kampala, Uganda--a respondent driven sampling survey.
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DOI：
10.1371/journal.pone.0038143
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Crane Survey Group
中科院分区：
文献类型：
--
作者：
Hladik W;Barker J;Ssenkusu JM;Opio A;Tappero JW;Hakim A;Serwadda D;Crane Survey Group
乌干达普遍的艾滋病毒流行情况得到了充分描述，包括估计坎帕拉成年男性艾滋病毒流行率为4.5%，但没有关于男男性行为者艾滋病毒感染流行率和风险因素的数据。从2008年5月至2009年2月，我们采用应答者驱动抽样方法，在坎帕拉招募了在过去三个月内报告与另一名男子发生肛交的≥18岁MSM。我们收集人口统计学和艾滋病毒相关的行为数据，通过音频计算机辅助自我管理的采访。实验室检测包括艾滋病毒和其他性传播感染的生物标志物。我们使用RDSAT和STATA获得了针对非随机抽样框架调整的人口估计值。300名男男性接触者接受了11次调查，中位年龄为25岁（四分位距，21-29岁）。总体HIV感染率为13.7%（95%置信区间[CI] 7.9%-20.1%），≥25岁的MSM（22.4%）高于18-24岁的MSM（3.9%，比值比[OR] 5.69，95% CI 2.02-16.02）。在多变量分析中，年龄≥25岁的MSM（调整OR [aOR] 4.32，95%CI 1.33-13.98）和报告曾暴露于同性恋虐待（言语，道德，性或身体虐待; aOR 5.38，95%CI 1.95-14.79）的人更有可能感染HIV。坎帕拉的男男性行为者感染艾滋病毒的风险大大高于一般成年男性人口。报告一生中有同性恋虐待史的男男性行为者感染艾滋病毒的风险增加。必须克服法律的挑战和污名化，提供有针对性的艾滋病毒预防和护理服务。
Uganda's generalized HIV epidemic is well described, including an estimated adult male HIV prevalence in Kampala of 4.5%, but no data are available on the prevalence of and risk factors for HIV infection among men who have sex with men (MSM). From May 2008 to February 2009, we used respondent-driven sampling to recruit MSM ≥18 years old in Kampala who reported anal sex with another man in the previous three months. We collected demographic and HIV-related behavioral data through audio computer-assisted self-administered interviews. Laboratory testing included biomarkers for HIV and other sexually transmitted infections. We obtained population estimates adjusted for the non-random sampling frame using RDSAT and STATA. 300 MSM were surveyed over 11 waves; median age was 25 years (interquartile range, 21–29 years). Overall HIV prevalence was 13.7% (95% confidence interval [CI] 7.9%–20.1%), and was higher among MSM ≥25 years (22.4%) than among MSM aged 18–24 years (3.9%, odds ratio [OR] 5.69, 95% CI 2.02–16.02). In multivariate analysis, MSM ≥25 years (adjusted OR [aOR] 4.32, 95% CI 1.33–13.98) and those reporting ever having been exposed to homophobic abuse (verbal, moral, sexual, or physical abuse; aOR 5.38, 95% CI 1.95–14.79) were significantly more likely to be HIV infected. MSM in Kampala are at substantially higher risk for HIV than the general adult male population. MSM reporting a lifetime history of homophobic abuse are at increased risk of being HIV infected. Legal challenges and stigma must be overcome to provide access to tailored HIV prevention and care services.
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影响因子：
3.6
作者：
Caceres, C.;Konda, K.;Lyerla, R.
通讯作者：
Lyerla, R.
影响因子：
3.8
作者：
Sanders, Eduard J.;Graham, Susan M.;Smith, Adrian D.
通讯作者：
Smith, Adrian D.
影响因子：
4.4
作者：
Kajubi, Phoebe;Kamya, Moses R.;McFarland, Willi
通讯作者：
McFarland, Willi
DOI：
10.1097/qai.0b013e3181f275e0
发表时间：
2010-12
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Glick SN;Golden MR
通讯作者：
Golden MR
影响因子：
5.5
作者：
Beyrer, Chris;Baral, Stefan D.;Sifakis, Frangiscos
通讯作者：
Sifakis, Frangiscos