Protein and energy substrate metabolism in AIDS patients.
Protein and energy substrate metabolism in AIDS patients.
复制标题
艾滋病患者的蛋白质和能量底物代谢。
DOI：
10.1016/0026-0495(90)90136-z
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Leskiw,MJ
中科院分区：
文献类型：
--
作者：
Stein,TP;Nutinsky,C;Condoluci,D;Schluter,MD;Leskiw,MJ
本研究的目的是研究无症状获得性免疫缺陷综合征（艾滋病）患者的蛋白质和葡萄糖代谢。9例无症状艾滋病患者与13例对照。我们测量了15n甘氨酸的全身蛋白质合成（PSRM）、分解（PBRM）和纤维蛋白原分数合成率，葡萄糖循环从2-d （Ra2-d）和6,6-d2（Ra6,6-d）标记葡萄糖的葡萄糖出现率之间的差异。所有这些参数在高代谢时升高，在营养不良时降低。此外，我们还测定了血浆氨基图。主要发现：(1)艾滋病患者全身蛋白质合成和分解及纤维蛋白原分步合成率显著降低；(2)艾滋病患者的葡萄糖循环明显降低，其主要原因是Ra2-d的降低；内源性葡萄糖生成速率Ra6,6d无显著差异；(3)血浆氨基酸图显示艾滋病组总氨基酸减少，必需氨基酸与非必需氨基酸的比例降低。我们的结论是，艾滋病患者表现出一种饥饿型反应。虽然蛋白质合成和能量底物循环的抑制不太可能是免疫缺陷的主要原因，但它们可能是导致患者对机会性感染的有效反应能力下降的重要促进因素。
The objective of this study was to investigate protein and glucose metabolism in ambulatory, asymptomatic acquired immunodeficiency syndrome (AIDS) patients. Nine asymptomatic AIDS patients were compared against 13 controls. We measured whole-body protein synthesis (PSRM), breakdown (PBRM), and the fractional fibrinogen synthesis rate with15N glycine, glucose cycling from the difference between the glucose appearance rates as measured with 2-d (Ra2-d)- and 6,6-d2(Ra6,6-d)-labeled glucose. All of these parameters are increased with hypermetabolism and decreased with undernutrition. In addition, we also determined the plasma aminogram. The principal findings were (1) whole-body protein synthesis and breakdown and the fibrinogen fractional synthesis rate were significantly lower in the AIDS patients; (2) glucose cycling was markedly lower in the AIDS patients, and most of this effect was due to a decrease in Ra2-d; there was no difference in the endogenous glucose production rate, Ra6,6d; and (3) the plasma aminogram showed decreased total amino acids and a reduced ratio of essential to nonessential amino acids in the AIDS group. We concluded that the AIDS patients showed a starvation-type response. While the depressed protein synthesis and energy substrate cycling are not likely to be the primary cause of immunodeficiency, they may represent an important facilitating factors contributing to the decreased ability of the patient to respond effectively to opportunistic infections.
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影响因子：
7.1
作者：
KOTLER, DP;WANG, J;PIERSON, RN
通讯作者：
PIERSON, RN
影响因子：
8.9
作者：
I. Rosenberg;J. Bengoa;M. Sitrin
通讯作者：
M. Sitrin
非必需 15N 标记氨基酸的代谢和人体全身蛋白质合成率的测量。
DOI：
10.1093/jn/116.9.1651
发表时间：
1986
期刊：
The Journal of nutrition
影响因子：
--
作者：
Stein,TP;Settle,RG;Albina,JA;Dempsey,DT;Melnick,G
通讯作者：
Melnick,G
在人类高胰岛素血症期间用 [6-3H]- 和 [6,6-2 H2]- 而不是 [6-14C] 葡萄糖测量的葡萄糖周转率被低估
影响因子：
7.7
作者：
M. Mcmahon;W. Schwenk;M. Haymond;R. Rizza
通讯作者：
R. Rizza
一名受试者体内氮的明显区隔：其在测量 15N 全身蛋白质合成率时的影响。
影响因子：
6
作者：
Edward Fern;P. Garlick;J. Waterlow
通讯作者：
J. Waterlow