Cell types, network homeostasis, and pathological compensation from a biologically plausible ion channel expression model.
Cell types, network homeostasis, and pathological compensation from a biologically plausible ion channel expression model.
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DOI：
10.1016/j.neuron.2014.04.002
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发表时间：
2014-05-21
期刊：
影响因子：
16.2
通讯作者：
Marder E
中科院分区：
文献类型：
--
作者：
O'Leary T;Williams AH;Franci A;Marder E
How do neurons develop, control, and maintain their electrical signaling properties in spite of ongoing protein turnover and perturbations to activity? From generic assumptions about the molecular biology underlying channel expression, we derive a simple model and show how it encodes an “activity set point” in single neurons. The model generates diverse self-regulating cell types and relates correlations in conductance expression observed in vivo to underlying channel expression rates. Synaptic as well as intrinsic conductances can be regulated to make a self-assembling central pattern generator network; thus, network-level homeostasis can emerge from cell-autonomous regulation rules. Finally, we demonstrate that the outcome of homeostatic regulation depends on the complement of ion channels expressed in cells: in some cases, loss of specific ion channels can be compensated; in others, the homeostatic mechanism itself causes pathological loss of function.
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影响因子：
64.8
作者：
Alon, U;Surette, MG;Leibler, S
通讯作者：
Leibler, S
影响因子：
16.2
作者：
Hengen KB;Lambo ME;Van Hooser SD;Katz DB;Turrigiano GG
通讯作者：
Turrigiano GG
影响因子：
4.3
作者：
Franci A;Drion G;Seutin V;Sepulchre R
通讯作者：
Sepulchre R
DOI：
10.1523/jneurosci.6042-11.2012
发表时间：
2012-05-23
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Lin WH;Günay C;Marley R;Prinz AA;Baines RA
通讯作者：
Baines RA
影响因子：
5.3
作者：
Amendola, Julien;Woodhouse, Adele;Goaillard, Jean-Marc
通讯作者：
Goaillard, Jean-Marc