Firing rate homeostasis in visual cortex of freely behaving rodents.
Firing rate homeostasis in visual cortex of freely behaving rodents.
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DOI：
10.1016/j.neuron.2013.08.038
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发表时间：
2013-10-16
期刊：
影响因子：
16.2
通讯作者：
Turrigiano GG
中科院分区：
文献类型：
--
作者：
Hengen KB;Lambo ME;Van Hooser SD;Katz DB;Turrigiano GG
据推测，稳态机制通过将神经元放电保持在设定点范围内来维持稳定的电路功能，但这种放电率稳态从未在体内得到证实。在这里，我们使用慢性多电极记录监测放电率的自由行为大鼠在慢性单眼视觉剥夺（MD）。V1的放电率在MD的前2天受到抑制，但随后在接下来的2-3天反弹到基线，尽管MD持续存在。这种放电的下降和反弹伴随着离体测量的mEPSC振幅的双向变化。放电的反弹是独立的睡眠-觉醒状态，但细胞类型特异性，作为推定的FS和定期尖峰神经元响应MD与不同的时间过程。这些数据首次建立了完整的中枢神经系统内的稳态机制，以稳定神经元的放电率在面对持续的感觉扰动。
It has been postulated that homeostatic mechanisms maintain stable circuit function by keeping neuronal firing within a set-point range, but such firing rate homeostasis has never been demonstrated in vivo. Here we use chronic multielectrode recordings to monitor firing rates in visual cortex of freely behaving rats during chronic monocular visual deprivation (MD). Firing rates in V1 were suppressed over the first 2 d of MD, but then rebounded to baseline over the next 2–3 d despite continued MD. This drop and rebound in firing was accompanied by bi-directional changes in mEPSC amplitude measured ex vivo. The rebound in firing was independent of sleep-wake state but was cell-type specific, as putative FS and regular spiking neurons responded to MD with different time-courses. These data establish for the first time that homeostatic mechanisms within the intact CNS act to stabilize neuronal firing rates in the face of sustained sensory perturbations.
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影响因子：
16.2
作者：
Khibnik, Lena A.;Cho, Kathleen K. A.;Bear, Mark F.
通讯作者：
Bear, Mark F.
影响因子：
16.2
作者：
Nelson SB;Turrigiano GG
通讯作者：
Turrigiano GG
DOI：
10.1523/jneurosci.4502-12.2013
发表时间：
2013-05-15
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Lambo ME;Turrigiano GG
通讯作者：
Turrigiano GG
影响因子：
64.8
作者：
Kirkwood, A;Rioult, MG;Bear, MF
通讯作者：
Bear, MF
影响因子：
16.2
作者：
Kaneko, Megumi;Stellwagen, David;Stryker, Michael P.
通讯作者：
Stryker, Michael P.