Inflammation in the CNS: Understanding Various Aspects of the Pathogenesis of Alzheimer's Disease.
Inflammation in the CNS: Understanding Various Aspects of the Pathogenesis of Alzheimer's Disease.
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DOI：
10.2174/1567205018666211202143935
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发表时间：
2022
影响因子：
2.1
通讯作者：
Kulczyńska-Przybik A
中科院分区：
文献类型：
--
作者：
Doroszkiewicz J;Mroczko P;Kulczyńska-Przybik A
阿尔茨海默病是一种进行性和致命的神经退行性疾病，是全球痴呆症最常见的原因之一。目前，早期诊断和监测这种疾病的方法不够敏感和具体，这促使人们寻找新的工具。大量文献资料表明，阿尔茨海默病（AD）的发病机制并不局限于神经元间室，而是涉及多种免疫机制。神经炎症已被认为是阿尔茨海默病的一个重要病理过程。它似乎在认知障碍的发展中发挥着多效作用，既具有神经保护作用，也具有神经退行性作用，这取决于疾病的阶段。越来越多的证据表明，炎症蛋白可以被认为是疾病进展的生物标志物。因此，本文综述了一些炎症分子的作用及其在检测和监测痴呆严重程度方面的潜在用途。这篇论文还对导致痴呆发展的新机制提供了有价值的见解，这可能有助于发现可能的抗炎治疗方法。
Alzheimer’s disease is a progressive and deadly neurodegenerative disorder and one of the most common causes of dementia globally. Current, insufficiently sensitive and specific methods of early diagnosing and monitoring this disease prompt a search for new tools. Numerous literature data have indicated that the pathogenesis of Alzheimer’s disease (AD) is not limited to the neuronal compartment but involves various immunological mechanisms. Neuroinflammation has been recognized as a very important process in AD pathology. It seems to play pleiotropic roles, both neuroprotective and neurodegenerative, in the development of cognitive impairment depending on the stage of the disease. Mounting evidence demonstrates that inflammatory proteins could be considered biomarkers of disease progression. Therefore, the present review summarizes the role of some inflammatory molecules and their potential utility in detecting and monitoring dementia severity. This paper also provides a valuable insight into new mechanisms leading to the development of dementia, which might be useful in discovering possible anti-inflammatory treatment.
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影响因子：
--
作者：
Abate G;Vezzoli M;Polito L;Guaita A;Albani D;Marizzoni M;Garrafa E;Marengoni A;Forloni G;Frisoni GB;Cummings JL;Memo M;Uberti D
通讯作者：
Uberti D
影响因子：
7.3
作者：
Chee SEJ;Solito E
通讯作者：
Solito E
影响因子：
6.8
作者：
Bonham LW;Karch CM;Fan CC;Tan C;Geier EG;Wang Y;Wen N;Broce IJ;Li Y;Barkovich MJ;Ferrari R;Hardy J;Momeni P;Höglinger G;Müller U;Hess CP;Sugrue LP;Dillon WP;Schellenberg GD;Miller BL;Andreassen OA;Dale AM;Barkovich AJ;Yokoyama JS;Desikan RS;International FTD-Genomics Consortium (IFGC);International Parkinson’s Disease Genetics Consortium (IPDGC);International Genomics of Alzheimer’s Project (IGAP)
通讯作者：
International Genomics of Alzheimer’s Project (IGAP)
影响因子：
4.2
作者：
Bachstetter, Adam D.;Morganti, Josh M.;Jernberg, Jennifer;Schlunk, Andrea;Mitchell, Staten H.;Brewster, Kaelin W.;Hudson, Charles E.;Cole, Michael J.;Harrison, Jeffrey K.;Bickford, Paula C.;Gemma, Carmelina
通讯作者：
Gemma, Carmelina
影响因子：
16.2
作者：
Bhaskar, Kiran;Konerth, Megan;Kokiko-Cochran, Olga N.;Cardona, Astrid;Ransohoff, Richard M.;Lamb, Bruce T.
通讯作者：
Lamb, Bruce T.