The Impact of Ageing on the CNS Immune Response in Alzheimer's Disease.
The Impact of Ageing on the CNS Immune Response in Alzheimer's Disease.
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DOI：
10.3389/fimmu.2021.738511
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发表时间：
2021
影响因子：
7.3
通讯作者：
Solito E
中科院分区：
文献类型：
--
作者：
Chee SEJ;Solito E
阿尔茨海默病（Alzheimer's Disease，AD）是一种与年龄增长密切相关的进行性神经退行性疾病。神经炎症和淀粉样蛋白的积累是这种疾病的标志之一，迄今为止，大多数转化研究都集中在靶向这两个过程。然而，AD的确切病因仍有待充分阐明。与之相比，AD的免疫应答与老年人中观察到的中枢神经系统（CNS）免疫变化非常相似。AD可能是继发于先前或正在进行的损伤的慢性刺激的老化免疫系统的病理结果。病理变化如淀粉样蛋白积累和神经元细胞死亡可能反映了这种免疫衰老过程，因为CNS免疫系统无法维持CNS中的稳态。未来设计用于调节老年免疫系统的治疗方法可能会证明对改变疾病进程有益。开发适当生物标志物的新检测方法对于筛选最有可能从此类治疗中获益的患者也至关重要。
Alzheimer’s Disease (AD) is a progressive neurodegenerative disease strongly associated with increasing age. Neuroinflammation and the accumulation of amyloid protein are amongst the hallmarks of this disease and most translational research to date has focused on targeting these two processes. However, the exact etiology of AD remains to be fully elucidated. When compared alongside, the immune response in AD closely resembles the central nervous system (CNS) immune changes seen in elderly individuals. It is possible that AD is a pathological consequence of an aged immune system secondary to chronic stimulation by a previous or ongoing insult. Pathological changes like amyloid accumulation and neuronal cell death may reflect this process of immunosenescence as the CNS immune system fails to maintain homeostasis in the CNS. It is likely that future treatments designed to modulate the aged immune system may prove beneficial in altering the disease course. The development of new tests for appropriate biomarkers would also be essential in screening for patients most likely to benefit from such treatments.
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影响因子：
13.6
作者：
Da Mesquita S;Herz J;Wall M;Dykstra T;de Lima KA;Norris GT;Dabhi N;Kennedy T;Baker W;Kipnis J
通讯作者：
Kipnis J
DOI：
10.3233/jad-179941
发表时间：
2018
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Cline EN;Bicca MA;Viola KL;Klein WL
通讯作者：
Klein WL
影响因子：
--
作者：
Baek H;Ye M;Kang GH;Lee C;Lee G;Choi DB;Jung J;Kim H;Lee S;Kim JS;Lee HJ;Shim I;Lee JH;Bae H
通讯作者：
Bae H
影响因子：
64.5
作者：
Dani N;Herbst RH;McCabe C;Green GS;Kaiser K;Head JP;Cui J;Shipley FB;Jang A;Dionne D;Nguyen L;Rodman C;Riesenfeld SJ;Prochazka J;Prochazkova M;Sedlacek R;Zhang F;Bryja V;Rozenblatt-Rosen O;Habib N;Regev A;Lehtinen MK
通讯作者：
Lehtinen MK
影响因子：
14
作者：
通讯作者：
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