Resveratrol Role in Autoimmune Disease-A Mini-Review.

Resveratrol Role in Autoimmune Disease-A Mini-Review.
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DOI:
10.3390/nu9121306
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发表时间:
2017-12-01
期刊:
影响因子:
5.9
通讯作者:
Monteiro MC
Monteiro MC
中科院分区:
医学2区
文献类型:
--
作者:
Oliveira ALB;Monteiro VVS;Navegantes-Lima KC;Reis JF;Gomes RS;Rodrigues DVS;Gaspar SLF;Monteiro MC

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自身免疫性疾病仍然被认为是紧迫的问题,因为它们是全世界死亡和残疾原因的主要原因。白藜芦醇是一种多酚,源自多种食品和饮料,包括红葡萄和红酒。据报道,白藜芦醇具有抗炎、抗氧化和抗衰老特性,在一些动物和人体研究中,这种化合物可以减少和改善自身免疫性疾病的进展,例如类风湿关节炎、系统性红斑狼疮、牛皮癣、炎症性肠病和 1 型糖尿病。因此,本综述旨在总结并批判性分析白藜芦醇在调节几种器官特异性或系统性自身免疫性疾病中的作用。
Autoimmune diseases are still considered to be pressing concerns due the fact that they are leaders in death and disability causes worldwide. Resveratrol is a polyphenol derived from a variety of foods and beverages, including red grapes and red wine. Anti-inflammatory, antioxidant, and antiaging properties of resveratrol have been reported, and in some animal and human studies this compound reduced and ameliorated the progression of autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, psoriasis, inflammatory bowel disease, and type 1 diabetes mellitus. Thus, this review aims to summarize and critically analyze the role of resveratrol in the modulation of several organ-specific or systemic autoimmune diseases.
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