Long Non-coding RNAs in Hepatitis C Virus-Infected Cells.
Long Non-coding RNAs in Hepatitis C Virus-Infected Cells.
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DOI：
10.3389/fmicb.2017.01833
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发表时间：
2017
影响因子：
5.2
通讯作者：
Fortes P
中科院分区：
文献类型：
--
作者：
Barriocanal M;Fortes P
丙型肝炎病毒（HCV）通常导致肝脏慢性感染，可能进展为脂肪变性、纤维化、肝硬化和肝细胞癌（HCC）。几种病毒和细胞因子是生产性感染和肝病发展所必需的。其中一些是在感染细胞中失调的长非编码RNA（lncRNA）。在HCV感染后，病毒RNA基因组的序列和结构被感知以激活干扰素（IFN）合成和信号传导途径。这些抗病毒途径调节几种细胞lncRNA的转录。其中一些也是为了应对病毒复制而解除管制的。某些病毒蛋白和/或病毒复制可激活转录因子，如MYC、SP1、NRF2或HIF 1 α，这些转录因子可调节其他细胞lncRNA的表达。有趣的是，到目前为止描述的HCV感染细胞中的几种失调的lncRNA通过充当IFN系统的正或负调节剂来发挥前病毒或抗病毒功能，而其他lncRNA有助于肝硬化和HCC的发展。对这些lncRNA的结构和作用机制的研究可能有助于开发治疗感染性和免疫性病理学以及肝硬化和HCC等肝脏疾病的新策略。
Hepatitis C virus (HCV) often leads to a chronic infection in the liver that may progress to steatosis, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Several viral and cellular factors are required for a productive infection and for the development of liver disease. Some of these are long non-coding RNAs (lncRNAs) deregulated in infected cells. After HCV infection, the sequence and the structure of the viral RNA genome are sensed to activate interferon (IFN) synthesis and signaling pathways. These antiviral pathways regulate transcription of several cellular lncRNAs. Some of these are also deregulated in response to viral replication. Certain viral proteins and/or viral replication can activate transcription factors such as MYC, SP1, NRF2, or HIF1α that modulate the expression of additional cellular lncRNAs. Interestingly, several lncRNAs deregulated in HCV-infected cells described so far play proviral or antiviral functions by acting as positive or negative regulators of the IFN system, while others help in the development of liver cirrhosis and HCC. The study of the structure and mechanism of action of these lncRNAs may aid in the development of novel strategies to treat infectious and immune pathologies and liver diseases such as cirrhosis and HCC.
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影响因子：
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作者：
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