Identification of microRNA-Associated-ceRNA Networks Regulating Crop Milk Production in Pigeon (Columba livia).
Identification of microRNA-Associated-ceRNA Networks Regulating Crop Milk Production in Pigeon (Columba livia).
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调节鸽子 (Columba livia) 作物产奶量的 microRNA 相关 ceRNA 网络的鉴定
DOI：
10.3390/genes12010039
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发表时间：
2020-12-30
期刊：
影响因子：
3.5
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Ge P;Ma H;Li Y;Ni A;Isa AM;Wang P;Bian S;Shi L;Zong Y;Wang Y;Jiang L;Hagos H;Yuan J;Sun Y;Chen J
鸽子属于另类。雏鸟不能独立觅食。营养只能从公鸽和母鸽分泌的庄稼奶中获得。MiRNA可以调节许多生物事件。然而，miRNA和Cerna在调节作物奶生产中的作用仍不清楚。在本研究中，我们调查了雌性鸽子作物miRNAs的表达谱，探索了潜在的关键基因，并发现了植物乳生产的调控机制。共鉴定出71个差异表达的miRNAs。同时发现miR-20b-5p、miR-146b-5p、miR-21-5p和miR-26b-5p是调节泌乳的关键miRNAs。这些miRNAs的靶基因主要参与细胞发育、蛋白质和脂肪合成以及细胞-细胞黏附、上皮细胞形态发生、钙信号通路、蛋白质消化和吸收等离子信号过程。在CERNA网络中，miR-193-5p位于中心位置，miR-193-5p/CREBRF/LOC110355588、miR-460b-5p/GRHL2/MSTRG.132954和miR-193-5p/PIK3CD/LOC110355588调节轴被认为影响哺乳。总之，我们的发现丰富了鸽子的miRNA表达谱，并为调控鸽子作物奶生产的microRNA相关-Cerna网络提供了新的见解。
Pigeon belongs to altrices. Squab cannot forage independently. Nutrition can only be obtained from crop milk secreted by male and female pigeon. miRNA could regulate many biological events. However, the roles of miRNA and ceRNA in regulating crop milk production are still unknown. In this study, we investigated the miRNAs expression profile of female pigeon crop, explored the potential key genes, and found the regulatory mechanisms of crop milk production. A total of 71 miRNAs were identified differentially expressed significantly. Meanwhile, miR-20b-5p, miR-146b-5p, miR-21-5p, and miR-26b-5p were found to be the key miRNAs regulating lactation. Target genes of these miRNAs participated mainly in cell development; protein and lipid synthesis; and ion signaling processes, such as cell-cell adhesion, epithelial cell morphogenesis, calcium signaling pathway, protein digestion, and absorption. In the ceRNA network, miR-193-5p was located in the central position, and miR-193-5p/CREBRF/LOC110355588, miR-460b-5p/GRHL2/MSTRG.132954, and miR-193-5p/PIK3CD/LOC110355588 regulatory axes were believed to affect lactation. Collectively, our findings enriched the miRNA expression profile of pigeon and provided novel insights into the microRNA-associated-ceRNA networks regulating crop milk production in pigeon.
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影响因子：
--
作者：
Al-Ansari MM;Aboussekhra A
通讯作者：
Aboussekhra A
影响因子：
64.8
作者：
Arif A;Terenzi F;Potdar AA;Jia J;Sacks J;China A;Halawani D;Vasu K;Li X;Brown JM;Chen J;Kozma SC;Thomas G;Fox PL
通讯作者：
Fox PL
影响因子：
7
作者：
Chen, Xiaoxu;Zheng, Yi;Zeng, Wenxian
通讯作者：
Zeng, Wenxian
Torc1的靶向破坏通过抑制繁殖鸽子（哥伦比亚利维亚）中农作牛奶蛋白的合成来抑制年轻的异类生长。
影响因子：
4.4
作者：
Chen MJ;Fu Z;Jiang SG;Wang XQ;Yan HC;Gao CQ
通讯作者：
Gao CQ
影响因子：
4.4
作者：
Aryal B;Singh AK;Rotllan N;Price N;Fernández-Hernando C
通讯作者：
Fernández-Hernando C