Extracellular matrix functions during neuronal migration and lamination in the mammalian central nervous system.
Extracellular matrix functions during neuronal migration and lamination in the mammalian central nervous system.
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DOI：
10.1002/dneu.20946
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发表时间：
2011-11
影响因子：
3
通讯作者：
Mueller, Ulrich
中科院分区：
文献类型：
--
作者：
Franco, Santos J.;Mueller, Ulrich
细胞外基质(ECM)糖蛋白在中枢神经系统(CNS)以复杂的发育调节模式表达。ECM在中枢神经系统中提供了许多关键功能，对中枢神经系统的整体结构组织和对单个细胞的控制都有贡献。在细胞水平上，ECM通过一系列机制影响其功能，包括为细胞提供结构支持，调节第二信使系统的活动，控制生长和分化因子的分布和局部浓度。也许ECM最广为人知的作用是作为一种底物，活动细胞可以在上面迁移。遗传学、细胞生物学和生化研究提供了强有力的证据，表明层粘连蛋白、肌腱蛋白和蛋白多糖等细胞外基质糖蛋白控制着发育中和成人大脑中几个区域的神经元迁移和定位。最近的发现也为reelin调节迁移的细胞和分子机制提供了重要的新见解。在这里，我们将总结这些发现，强调一个新兴的概念，即ECM糖蛋白促进不同的神经元迁移模式，如径向、切向和链迁移。我们还讨论了几项研究，证明ECM糖蛋白的突变可以通过细胞非自治机制改变神经元的位置，从而继而影响迁移的神经元。
Extracellular matrix (ECM) glycoproteins are expressed in the central nervous system (CNS) in complex and developmentally regulated patterns. The ECM provides a number of critical functions in the CNS, contributing both to the overall structural organization of the CNS and to control of individual cells. At the cellular level, the ECM effects its functions by a wide range of mechanisms, including providing structural support to cells, regulating the activity of second messenger systems, and controlling the distribution and local concentration of growth and differentiation factors. Perhaps the most well known role of the ECM is as a substrate on which motile cells can migrate. Genetic, cell biological and biochemical studies provide strong evidence that ECM glycoproteins such as laminins, tenascins and proteoglycans control neuronal migration and positioning in several regions of the developing and adult brain. Recent findings have also shed important new insights into the cellular and molecular mechanisms by which reelin regulates migration. Here we will summarize these findings, emphasizing the emerging concept that ECM glycoproteins promote different modes of neuronal migration such as radial, tangential and chain migration. We also discuss several studies demonstrating that mutations in ECM glycoproteins can alter neuronal positioning by cell non-autonomous mechanisms that secondarily affect migrating neurons.
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影响因子：
30.8
作者：
Assadi, AH;Zhang, GC;Clark, GD
通讯作者：
Clark, GD
影响因子：
4.6
作者：
Campos, LS;Leone, DP;ffrench-Constant, C
通讯作者：
ffrench-Constant, C
影响因子：
5.3
作者：
Beffert, U;Durudas, A;Herz, J
通讯作者：
Herz, J
影响因子：
5.2
作者：
Akita, Kaoru;von Holst, Alexander;Faissner, Andreas
通讯作者：
Faissner, Andreas
影响因子：
3
作者：
Baeten, Kim M.;Akassoglou, Katerina
通讯作者：
Akassoglou, Katerina