Membrane trafficking in morphogenesis and planar polarity.
Membrane trafficking in morphogenesis and planar polarity.
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DOI：
10.1111/tra.12580
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发表时间：
2018-05-14
期刊：
影响因子：
--
通讯作者：
Blankenship JT
中科院分区：
文献类型：
--
作者：
Xie Y;Miao H;Blankenship JT
Our understanding of how membrane trafficking pathways function to direct morphogenetic movements and the planar polarization of developing tissues is a new and emerging field. While a central focus of developmental biology has been on how protein asymmetries and cytoskeletal force generation direct cell shaping, the role of membrane trafficking in these processes has been less clear. Here, we review recent advances in Drosophila and vertebrate systems in our understanding of how trafficking events are coordinated with planar cytoskeletal function to drive lasting changes in cell and tissue topologies. We additionally explore the function of trafficking pathways in guiding the complex interactions that initiate and maintain core PCP (Planar Cell Polarity) asymmetries and drive the generation of systemically oriented cellular projections during development.
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