Transcription dynamics.

Transcription dynamics.
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DOI:
10.1016/j.molcel.2009.09.005
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发表时间:
2009-09-24
期刊:
影响因子:
16
通讯作者:
Misteli T
Misteli T
中科院分区:
生物学1区
文献类型:
--
作者:
Hager GL;McNally JG;Misteli T

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转录及其调控的所有方面都涉及动态事件。基础的转录机制和调控成分被动态地募集到它们的靶基因中,并且转录因子与染色质的动态相互作用以及它们之间的动态相互作用在RNA聚合酶的组装、起始和延伸中起着关键作用。这些转录因子的短期结合动力学被染色质开放和转录因子结合事件的长期循环行为叠加。它的动态性质不仅是转录机制的基本性质,而且正在成为生理过程的重要调节剂,特别是在分化和发育中。
All aspects of transcription and its regulation involve dynamic events. The basal transcription machinery and regulatory components are dynamically recruited to their target genes, and dynamic interactions of transcription factors with chromatin—and with each other—play a key role in RNA polymerase assembly, initiation, and elongation. These short-term binding dynamics of transcription factors are superimposed by long-term cyclical behavior of chromatin opening and transcription factor-binding events. Its dynamic nature is not only a fundamental property of the transcription machinery, but it is emerging as an important modulator of physiological processes, particularly in differentiation and development.
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