Plasma Macrophage Migration Inhibitory Factor Predicts Graft Function Following Kidney Transplantation: A Prospective Cohort Study.
Plasma Macrophage Migration Inhibitory Factor Predicts Graft Function Following Kidney Transplantation: A Prospective Cohort Study.
复制标题
血浆巨噬细胞迁移抑制因子预测肾移植后的移植物功能：一项前瞻性队列研究
DOI：
10.3389/fmed.2021.708316
复制
发表时间：
2021
影响因子：
3.9
通讯作者：
Sun Q
中科院分区：
文献类型：
--
作者：
Ye Y;Han F;Ma M;Sun Q;Huang Z;Zheng H;Yang Z;Luo Z;Liao T;Li H;Hong L;Na N;Sun Q
背景：移植肾功能延迟恢复（DGF）是肾移植（KT）后常见的并发症，临床预后差。目前还没有准确的生物标志物用于DGF的早期预测。巨噬细胞移动抑制因子（macrophage migration inhibitor factor，MIF）在肾移植术后的释放中起着保护肾脏的重要作用，可能成为预测移植肾恢复的潜在生物标志物。方法：本研究招募了2020年7月至2020年12月期间接受KT的受试者。检测不同时间点受者血浆MIF水平，并分析其与DGF的相关性。本研究已在中国临床试验注册中心（ChiCTR 2000035596）注册。结果：术中移植肾功能即刻恢复组、缓慢恢复组和延迟恢复组的MIF水平不同（7.26 vs.6.49和5.59，P < 0.001）。血浆MIF是DGF的独立保护因素（OR = 0.447，95%可信区间[CI] 0.264-0.754，P = 0.003）。联合血浆MIF水平和供体终末血清肌酐水平为DGF提供了最佳预测能力（0.872; 95%CI 0.795-0.949）。术后1个月血浆MIF水平与移植肾功能显著相关（R2 = 0.42，P < 0.001）。结论：术中MIF作为DGF的独立保护因子，对DGF的预测有很好的诊断价值，值得进一步探讨。
Background: Delayed graft function (DGF) is a common complication after kidney transplantation (KT) with a poor clinical outcome. There are no accurate biomarkers for the early prediction of DGF. Macrophage migration inhibitory factor (MIF) release during surgery plays a key role in protecting the kidney, and may be a potential biomarker for predicting post-transplant renal allograft recovery. Methods: Recipients who underwent KT between July 2020 and December 2020 were enrolled in the study. Plasma MIF levels were tested in recipients at different time points, and the correlation between plasma MIF and DGF in recipients was evaluated. This study was registered in the Chinese Clinical Trial Registry (ChiCTR2000035596). Results: Intraoperative MIF levels were different between immediate, slowed, and delayed graft function groups (7.26 vs. 6.49 and 5.59, P < 0.001). Plasma MIF was an independent protective factor of DGF (odds ratio = 0.447, 95% confidence interval [CI] 0.264–0.754, P = 0.003). Combining plasma MIF level and donor terminal serum creatinine provided the best predictive power for DGF (0.872; 95%CI 0.795–0.949). Furthermore, plasma MIF was significantly associated with allograft function at 1-month post-transplant (R2 = 0.42, P < 0.001). Conclusion: Intraoperative MIF, as an independent protective factor for DGF, has excellent diagnostic performance for predicting DGF and is worthy of further exploration.
登录
查看更多内容
影响因子：
6.2
作者：
Huang, Jiefu;Wang, Haibo;Liu, Yongfeng
通讯作者：
Liu, Yongfeng
影响因子：
3.7
作者：
Payen D;Lukaszewicz AC;Legrand M;Gayat E;Faivre V;Megarbane B;Azoulay E;Fieux F;Charron D;Loiseau P;Busson M
通讯作者：
Busson M
影响因子：
4.6
作者：
Hong MY;Tseng CC;Chuang CC;Chen CL;Lin SH;Lin CF
通讯作者：
Lin CF
移植物功能延迟与扩展标准而非标准标准供肾受者的移植物丢失相关：一项回顾性、多中心、观察队列研究
影响因子：
6.1
作者：
Han, Fei;Lin, Min-Zhuan;Sun, Qi-Quan
通讯作者：
Sun, Qi-Quan
影响因子：
19.6
作者：
Hollmen, Maria E.;Kyllonen, Lauri E.;Salmela, Kaija T.
通讯作者：
Salmela, Kaija T.