Urinary macrophage migration inhibitory factor serves as a potential biomarker for acute kidney injury in patients with acute pyelonephritis.
Urinary macrophage migration inhibitory factor serves as a potential biomarker for acute kidney injury in patients with acute pyelonephritis.
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DOI：
10.1155/2012/381358
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发表时间：
2012
影响因子：
4.6
通讯作者：
Lin CF
中科院分区：
文献类型：
--
作者：
Hong MY;Tseng CC;Chuang CC;Chen CL;Lin SH;Lin CF
临床医生熟悉的常规肾功能标志物，包括血清肌酐和血尿素氮水平，无法揭示肾脏的真正损伤，并且它们的使用可能会延迟治疗。巨噬细胞移动抑制因子（MIF）是一种促炎细胞因子，其在急性肾损伤（阿基）肾脏感染中的预测作用和致病机制尚不清楚。在这项研究中，我们发现尿MIF水平升高伴随急性肾盂肾炎（APN）患者肾脏感染期间阿基的发展。除尿MIF水平外，尿白细胞介素（IL）-1β和肾损伤分子（KIM）-1水平也明显升高，且与尿MIF水平呈正相关。尿MIF水平升高，沿着IL-1β和KIM-1水平升高，被推测为APN患者中存在阿基的潜在生物标志物。
Conventional markers of kidney function that are familiar to clinicians, including the serum creatinine and blood urea nitrogen levels, are unable to reveal genuine injury to the kidney, and their use may delay treatment. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine, and the predictive role and pathogenic mechanism of MIF deregulation during kidney infections involving acute kidney injury (AKI) are not currently known. In this study, we showed that elevated urinary MIF levels accompanied the development of AKI during kidney infection in patients with acute pyelonephritis (APN). In addition to the MIF level, the urinary levels of interleukin (IL)-1β and kidney injury molecule (KIM)-1 were also upregulated and were positively correlated with the levels of urinary MIF. An elevated urinary MIF level, along with elevated IL-1β and KIM-1 levels, is speculated to be a potential biomarker for the presence of AKI in APN patients.
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影响因子：
6.2
作者：
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通讯作者：
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影响因子：
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DOI：
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发表时间：
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影响因子：
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作者：
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影响因子：
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通讯作者：
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