Stress-induced dendritic remodeling in the medial prefrontal cortex: effects of circuit, hormones and rest.
Stress-induced dendritic remodeling in the medial prefrontal cortex: effects of circuit, hormones and rest.
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DOI：
10.1016/j.brainres.2009.03.062
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发表时间：
2009-10-13
期刊：
影响因子：
2.9
通讯作者：
Morrison JH
中科院分区：
文献类型：
--
作者：
Shansky RM;Morrison JH
The medial prefrontal cortex (mPFC) has been implicated as a site of dysfunction and abnormal morphology in major depressive disorder and post-traumatic stress disorder, two illnesses that can be brought on by exposure to stress. In animal models, stress has long been shown to induce impairments in tasks known to be mediated by the mPFC, and recent work has demonstrated that chronic stress can lead to morphological changes in mPFC pyramidal cells. This review explores the current literature on stress-induced dendritic remodeling in the mPFC, with particular focus on new findings that illuminate modulators of these effects.
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