Demonstration of herpes group virus in acute retinal necrosis syndrome.

Demonstration of herpes group virus in acute retinal necrosis syndrome.
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疱疹病毒在急性视网膜坏死综合征中的演示。

DOI:
10.1016/0002-9394(86)90396-x
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发表时间:
1986
影响因子:
4.2
通讯作者:
Bowe,B
Bowe,B
中科院分区:
医学1区
文献类型:
--
作者:
Freeman,WR;Thomas,EL;Rao,NA;Pepose,JS;Trousdale,MD;Howes,EL;Nadel,AJ;Mines,JA;Bowe,B

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病理检查的组织取自三例急性视网膜坏死综合征。在两名患者的视网膜活检中发现了属于疱疹病毒家族的病毒颗粒,其中一名患者免疫抑制。尽管切除了大的活检标本,但在一个病例中,视网膜在术后20个月仍保持附着,在另一个病例中保持附着3个月。在第三例获得性免疫缺陷综合征患者中,临床病程和死后免疫病理学提示单纯疱疹病毒感染,最初影响视网膜,随后影响视神经、视交叉、视束和中枢神经系统。这些病例说明,与急性视网膜坏死综合征相关的病毒很容易在疾病的急性期使用玻璃体切除术和视网膜内活检证实,但在慢性脱离的萎缩性视网膜中可能很难证实。
Tissue for pathologic examination was obtained from three cases of acute retinal necrosis syndrome. Virus particles belonging to the herpesvirus family were demonstrated in retinal biopsies from two patients, one of whom was immunosuppressed. Despite removal of large biopsy specimens, the retina has remained attached for 20 months postoperatively in one case and for three months in the other. In a third patient with acquired immune deficiency syndrome, the clinical course and postmortem immunopathology were suggestive of a herpes simplex virus infection, initially affecting the retina and subsequently the optic nerves, chiasm, tracts, and central nervous system. These cases illustrate that the virus associated with the acute retinal necrosis syndrome is easily demonstrable using vitrectomy and endoretinal biopsy in the acute phase of the disease, but may be difficult to demonstrate in chronically detached atrophic retinas.
急性视网膜坏死综合征的玻璃体切除术和玻璃体内抗病毒药物治疗。
DOI: 10.1001/archopht.1984.01040031308013
发表时间: 1984
影响因子: --
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水痘带状疱疹病毒是急性视网膜坏死综合征的病因。
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急性视网膜坏死患者体内含有疱疹病毒抗原的免疫复合物。
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DOI: 10.1016/s0161-6420(84)34109-4
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影响因子: 13.7
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