The pros and cons of phytoestrogens.
The pros and cons of phytoestrogens.
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DOI：
10.1016/j.yfrne.2010.03.003
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发表时间：
2010-10
影响因子：
7.4
通讯作者：
Jefferson, Wendy
中科院分区：
文献类型：
--
作者：
Patisaul, Heather B.;Jefferson, Wendy
植物雌激素是一种植物来源的化合物，广泛存在于各种食物中，尤其是大豆。一系列的健康益处，包括降低骨质疏松、心脏病、乳腺癌和更年期症状的风险，通常被归因于植物雌激素，但许多也被认为是内分泌干扰物，表明它们也有可能导致不利的健康影响。因此，植物雌激素对人类健康是有益还是有害的问题仍然没有解决。答案可能很复杂，可能取决于年龄、健康状况，甚至是特定肠道微生物群的存在或不存在。这个问题需要澄清，因为全球消费正在迅速增加。植物雌激素存在于许多膳食补充剂中，并作为雌激素替代疗法的天然替代品被广泛销售。大豆婴儿配方奶粉现在占美国市场的三分之一，大豆蛋白现在被添加到许多加工食品中。作为弱雌激素激动剂/拮抗剂，其分子和细胞特性类似于合成的内分泌干扰物，如双酚A(BPA)，植物雌激素为全面研究内分泌干扰物的生物学影响提供了一个有用的模型。这篇综述权衡了支持和反对植物雌激素声称的健康益处和不利影响的证据。
Phytoestrogens are plant derived compounds found in a wide variety of foods, most notably soy. A litany of health benefits including a lowered risk of osteoporosis, heart disease, breast cancer, and menopausal symptoms, are frequently attributed to phytoestrogens but many are also considered endocrine disruptors, indicating that they have the potential to cause adverse health effects as well. Consequently, the question of whether or not phytoestrogens are beneficial or harmful to human health remains unresolved. The answer is likely complex and may depend on age, health status, and even the presence or absence of specific gut microflora. Clarity on this issue is needed because global consumption is rapidly increasing. Phytoestrogens are present in numerous dietary supplements and widely marketed as a natural alternative to estrogen replacement therapy. Soy infant formula now constitutes up to a third of the US market, and soy protein is now added to many processed foods. As weak estrogen agonists/antagonists with molecular and cellular properties similar to synthetic endocrine disruptors such as Bisphenol A (BPA), the phytoestrogens provide a useful model to comprehensively investigate the biological impact of endocrine disruptors in general. This review weighs the evidence for and against the purported health benefits and adverse effects of phytoestrogens.
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DOI：
10.1111/j.1751-0813.1946.tb15473.x
发表时间：
1946-01-01
期刊：
AUSTRALIAN VET JOUR
影响因子：
--
作者：
Bennetts, H. W.;Underwood, E. J.;Shier, F. L.
通讯作者：
Shier, F. L.
影响因子：
3
作者：
Beher, Dirk;Wu, John;Wang, Minghan
通讯作者：
Wang, Minghan
影响因子：
10.4
作者：
Barrett, JR
通讯作者：
Barrett, JR
DOI：
10.3181/00379727-217-44243
发表时间：
1998-03-01
影响因子：
--
作者：
Anderson, JJB;Ambrose, WW;Garner, SC
通讯作者：
Garner, SC
影响因子：
64.8
作者：
Baur, Joseph A.;Pearson, Kevin J.;Sinclair, David A.
通讯作者：
Sinclair, David A.