Research Progress of TXNIP as a Tumor Suppressor Gene Participating in the Metabolic Reprogramming and Oxidative Stress of Cancer Cells in Various Cancers.
Research Progress of TXNIP as a Tumor Suppressor Gene Participating in the Metabolic Reprogramming and Oxidative Stress of Cancer Cells in Various Cancers.
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TXNIP作为抑癌基因参与多种癌症中癌细胞代谢重编程和氧化应激的研究进展
DOI：
10.3389/fonc.2020.568574
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发表时间：
2020
影响因子：
4.7
通讯作者：
Zhang B
中科院分区：
文献类型：
--
作者：
Chen Y;Ning J;Cao W;Wang S;Du T;Jiang J;Feng X;Zhang B
硫氧还蛋白相互作用蛋白（TXNIP）是一种硫氧还蛋白结合蛋白，可以介导氧化应激，抑制细胞增殖，并通过抑制硫氧还蛋白系统的功能诱导细胞凋亡。TXNIP是重要的，因为它在心血管疾病、神经退行性疾病、癌症、糖尿病和其他疾病中具有广泛的功能。越来越多的证据表明，TXNIP在肿瘤中的表达较低，并且它可能在各种癌症类型如肝癌、乳腺癌和肺癌中起肿瘤抑制剂的作用。已知TXNIP通过影响代谢重编程来抑制乳腺癌细胞的增殖，并可以通过TXNIP-HIF 1 α-TWIST信号轴影响乳腺癌细胞的侵袭和迁移。TXNIP还可以通过抑制ERK的激活来预防膀胱癌的发生，ERK抑制膀胱癌细胞的凋亡。在这篇综述中，我们发现TXNIP可以通过与转录因子或其他结合蛋白结合来调节，也可以通过表观遗传变化或miRNA来下调。此外，我们还总结了新的见解TXNIP的表达及其在不同类型的癌症中的功能作用，以及阐明其参与代谢重编程和氧化应激在癌细胞中，其中它作为一个假定的肿瘤抑制基因，以抑制不同的肿瘤细胞的增殖，侵袭和迁移，以及促进这些细胞的凋亡。因此，TXNIP可能为寻找新的分子靶点，以促进恶性肿瘤的诊断和治疗具有基础和临床意义。
Thioredoxin-interacting protein (TXNIP) is a thioredoxin-binding protein that can mediate oxidative stress, inhibit cell proliferation, and induce apoptosis by inhibiting the function of the thioredoxin system. TXNIP is important because of its wide range of functions in cardiovascular diseases, neurodegenerative diseases, cancer, diabetes, and other diseases. Increasing evidence has shown that TXNIP expression is low in tumors and that it may act as a tumor suppressor in various cancer types such as hepatocarcinoma, breast cancer, and lung cancer. TXNIP is known to inhibit the proliferation of breast cancer cells by affecting metabolic reprogramming and can affect the invasion and migration of breast cancer cells through the TXNIP-HIF1α-TWIST signaling axis. TXNIP can also prevent the occurrence of bladder cancer by inhibiting the activation of ERK, which inhibits apoptosis in bladder cancer cells. In this review, we find that TXNIP can be regulated by binding to transcription factors or other binding proteins and can also be downregulated by epigenetic changes or miRNA. In addition, we also summarize emerging insights on TXNIP expression and its functional role in different kinds of cancers, as well as clarify its participation in metabolic reprogramming and oxidative stress in cancer cells, wherein it acts as a putative tumor suppressor gene to inhibit the proliferation, invasion, and migration of different tumor cells as well as promote apoptosis in these cells. TXNIP may therefore be of basic and clinical significance for finding novel molecular targets that can facilitate the diagnosis and treatment of malignant tumors.
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影响因子：
3.8
作者：
Daoud, Afra Z.;Mulholland, Eoghan J.;McCarthy, Helen O.
通讯作者：
McCarthy, Helen O.
CircRNA cRAPGEF5 通过 miR-27a-3p/TXNIP 通路抑制肾细胞癌的生长和转移。
影响因子：
9.7
作者：
Chen, Qiong;Liu, Tao;Wang, Linhui
通讯作者：
Wang, Linhui
影响因子：
5.7
作者：
Feingold PL;Surman DR;Brown K;Xu Y;McDuffie LA;Shukla V;Reardon ES;Crooks DR;Trepel JB;Lee S;Lee MJ;Gao S;Xi S;McLoughlin KC;Diggs LP;Beer DG;Nancarrow DJ;Neckers LM;Davis JL;Hoang CD;Hernandez JM;Schrump DS;Ripley RT
通讯作者：
Ripley RT
影响因子：
3.7
作者：
Devi TS;Hosoya K;Terasaki T;Singh LP
通讯作者：
Singh LP
影响因子：
--
作者：
Chen D;Dang BL;Huang JZ;Chen M;Wu D;Xu ML;Li R;Yan GR
通讯作者：
Yan GR